The following scientists have been awarded the BSIO Female Independency Award so far

Please click on names and headline "Brief CV and Research profile" for further information:

Awardees 2013

Dr. Angela Relogio

Awardees 2014

Dr. Michela di Virgilio

Awardees 2015

Michela Serresi, PhD

Affiliation: Associate Staff scientist, Max Delbrück Center for Molecular Medicine, Berlin (MDC)

Project title: Molecular mechanisms underlying lung cancer dissemination to the brain

 

Brief CV and Research profile

University Education

11/1997 Master Degree cum laude in Biological Sciences, Universita’ Politecnica delle Marche”, Ancona, Italy

12/2003. PhD in Applied Biomolecular Science, Universita’ Politecnica delle Marche, Ancona, Italy.

Research experience

(Present appointment) Associate Staff Scientist, Molecular Oncology, Max Delbruck Center, Berlin Germany - Project Leader -BSIO Female Independency Award- Berlin, School of Integrative Oncology

(Oct-10 to Sept 16): Postdoctoral fellow, Division of Molecular Genetics, Netherland Cancer Institute, Amsterdam, The Netherlands (NKI).
Jan-10 to Sept-10: Team Leader, IIT@CNI NEST- Scuola Normale Superiore Pisa, Italy

Jan-2006 to Dec-09: Senior Scientist, Scuola Normale Superiore, Pisa, Italy 

Jan-2004 to Dec-2005: Postdoctoral fellow, Division of Experimental Oncology II European Institute of Oncology, Milan, Italy

Sep-2001 – Dec-2003 Visiting Scientist at the European Institute of Oncology, Milan, Italy
Jan-2000 - Dec-2003: Pre-doctoral research position in the laboratory of Molecular Biology Universita’ Politecnica delle Marche, Ancona, Italy

Awards, honours

- 2015 BSIO Female Independency Award, Berlin School of Integrative Oncology (BSIO), Berlin, Germany

- 2012 Award of the National Scientific Habilitation (" Abilitazione Scientifica Nazionale") as Associate Professor (scientific area Applied Biology 05/F1), Italy

- 2010 Co-Chair at the International Meeting “Biophysical Society 54th Annual Meeting” (Platform AS “Exocytosis and Endocytosis”) 20-24 february 2014 San Francisco, California

- 2006-2008 Principal Investigator of Workpackage II “Drugs, Nanoreporters and Nanoactuators Delivery” Joined Project Scuola Normale Superiore –Italian Institute of Technology, Italy

- 2000-2002 Research Scientist Fellowship from FIRC (Fondazione Italiana Ricerca sul Cancro), Italy

Research fields

 ·         Molecular oncology

·         Cancer biology

Scientific Scope and Goals

The brain is one of the most common sites for lung adenocarcinoma metastasis. Approximately 20-30% of lung cancer patients develop brain metastasis and their prognosis is dismal, with a median survival of less than six months. Thus, understanding the mechanisms underlying this process is urgent to identify high-risk patients and design dedicated therapies. The focus of my research activity is to mechanistically dissect the events underlying brain metastasis. In the long term, our work will also contribute towards the identification of predictive biomarkers and novel targets for therapy.

Most relevant pubblications (selection)

1.  Gargiulo G, Citterio E, Serresi M Polycomb and lung cancer: when the dosage makes the (kind of) poisonMol Cell Oncol 2016 Feb, 24  DOI:10.1080/23723556.2016.1152345

2. Serresi M, Gargiulo G, Proost N, Siteur B, Cesaroni M, Koppens M, Xie H, Sutherland KD, Hulsman D, Citterio E, Orkin S, Berns A and van Lohuizen M. Polycomb repressive complex-2 is a barrier to Kras-driven inflammation and epithelial-mesenchymal transition in non-small cell lung cancerCancer Cell 2016 Jan 11;29(1):17-31. doi: 10.1016/j.ccell.2015.12.006.

3. Gargiulo G, Serresi M, Cesaroni M, Hulsman D, van Lohuizen In vivo shRNA screens in solid tumors. Nature Protocol 2014 Dec 9;(12): 2880-902

4. Gargiulo G, Cesaroni M, Serresi M, de Vries N, Hulsman D, Bruggeman SW, Lancini C, van Lohuizen M In vivo RNAi screen for BMI1 targets identifies TGF-B/BMP-ER stress pathway as key regulators of neural- and malignant glioma stem cell homeostasis. Cancer Cell 2013 May 13; 23(5):660-76

5. Serresi M*, Bizzarri R, Cardarelli F, Beltram F Real-time measurement of endosomal acidification by a novel genetically encoded biosensor. Analytical and bioanalytical chemistry. 2009 Feb;393(4):1123-33 (*corresponding author)

6. Pece S, Serresi M, Santolini E, Capra M, Hulleman E, Galimberti V, Zurrida S, Maisonneuve P, Viale G, Di Fiore PP Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. The Journal of cell biology. 2004 Oct 25;167(2):215-21

7. Serresi M, Piccinini G, Pierpaoli E, Fazioli F A ligand-inducible anaplastic lymphoma kinase chimera is endocytosis impaired. Oncogene. 2004 Feb 5;23(5):1098-108

 

PD Dr. Il-Kang Na

Affiliation: Medical Department for Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin

Project title: Strategies to support immune reconstitution after allogeneic hematopoietic stem cell transplantation and to improve the efficacy of adoptive tumor-specific T cell therapy