Dr. Angela Relogio, PhD

Research group leader, Charité - Universitätsmedizin Berlin and Humboldt University Berlin

Brief CV & Research focus

University Education

  • 2003 PhD in Biomedical Sciences Molecular and Cellular Biology,Faculty of Medicine, University of Lisbon, and the International PhD Programme of the EMBL, Heidelberg, (very good with honours)
  • 1999 Post-graduation in Biophysics and Biomedical Engineering, Faculty of Sciences, University of Lisbon
  • 1998 Diploma in Technological-Physics Engineering, Superior Technical Institute (IST), University of Lisbon           

Professional Experience

  • 2014 Group leader, Charité Medical University of Berlin
  • 2012-2014 Project leader, Rahel-Hirsch fellow, Charité Medical University of Berlin
  •  2007-2012 Research Scientist, Institute for Theoretical Biology, Charité Medical University of Berlin
  •  2003-2006 Postdoctoral fellow, European Molecular Biology Laboratory (EMBL), Heidelberg

Research Fields

  • i)    Cancer Biology
  • ii)  Systems Biology
  • iii)  Circadian clock

Scientific Scope and Goals

All cells hold an internal clock able to generate daily-endogenous rhythms. These endogenous rhythms are detected in 10% of all genes and provide a way to react to external clues, to anticipate behaviour and to adapt molecular processes to specific day-times. Malfunctions of the circadian clock have been reported in the context of many diseases and disorders. Cancer is one such disease which is directly correlated to perturbations of the circadian system, although the mechanisms involved are not yet clear.

Our group will combine experimental and theoretical methods to investigate the correlations between the circadian clock and tumourigenesis. Together with experimental molecular biology methods and high-throughput expression analysis, we use computational methods as well. These include mathematical modelling for the dynamic analysis of genetic networks and bioinformatics methods for the analysis of high-throughput data (from mammalian tumour cell lines and tissues). Using a systems biology approach we will examine genetic characteristics of tumours with different circadian properties and thereby try to understand the role of a deregulated clock in tumour development.

Most important Awards, Grants or Scientific Achievements

  • Female Independency Award (FIA) from the Berlin School of Integrative Oncology (BSIO), Charité Medical University of Berlin, Germany
  • Young Investigator’s Group – Grant from the BMBF, Germany
  • Rahel-Hirsch-excellence award, Charité Medical University of Berlin, Germany 
  • Postdoctoral fellowship from the European Molecular Biology Laboratory (EMBL), Germany
  • PhD fellowship-Praxis XXI programme from the Foundation for Science and Technology, Ministry for Science and Technology, Portugal and the European Molecular Biology Laboratory (EMBL), Germany

5 most relevant Publications

  • Relógio A. Medina-Perez P., Thomas P., Gloc E., Bervoets S., Maier B., Schaefer R., Leser U., Herzel H., Kramer A., Sers C. (2014). Ras – mediated deregulation of the circadian clock in cancer. PLoS Genetics.
  • Relógio A., Westermark P., Wallach T., Schellenberg K., Kramer A., Herzel H. (2011). Tuning the Mammalian Circadian Clock: Robust Synergy of Two loops. PLoS Computational Biology.
  • Bozek K* Relógio A*, Kielbasa SM, Heine M, Dame C, Kramer A, Herzel H. (2009). Regulation of clock-controlled genes in mammals. PLoS One.
  • Relógio A., Ben-Dov C., Baum M., Ruggiu M., Gemund C., Benes V., Darnell RB., Valcarcel J. (2005). Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodgkin lymphoma cells. Journal of Biological Chemistry.
  • Relógio A., Schwager C., Richeter, A., Ansorge W., Valcárcel J. (2002). Optimization of oligonucleotide-based DNA microarrays. Nucleic Acids Research.

Perspectives for Future PhD Thesis Projects

We seek higly motivated students with a background in physics, mathematics, informatics or biology, to work in interdisciplinary projects involving wet lab work, mathematical modelling and bioinformatics. Our group cooperates with several groups within the BSIO School and also with institutes outside Berlin such as the European Molecular Biology Laboratory (EMBL) in Heidelberg, the Institute for Molecular Medicine (IMM) in Lisbon and the Centre for Genomic Regulation (CRG) in Barcelona. We have open positions for both wetlab and computational projects. Available projects include mathematical modelling of the circadian clock and circadian networks in a cancer context and analysis of alternative splicing switches in tumorigenesis. We are looking forward for your application.