Prof. Dr. med. Kirsten Kübler

Most important Awards, Grants or Scientific Achievements

• 12.2022            Named one of the 100 women of the year in Germany by an independent jury of the FOCUS                                     magazine for contributing to cancer research
• 03.2019            Dr. Charles Chalfant Scholar-in-Training Award, AACR Annual Meeting Atlanta, Georgia, USA
• 11.2018            The Douglass Family Foundation Prize 2018 recognizing excellence in research

Scientific Scope

The Kübler lab is an interdisciplinary research group at the intersection of molecular biology, computational biology, and medical oncology. The overall goal of the lab is to gain a comprehensive molecular understanding of how cancer evolves genomically. While advanced tumors are often characterized by heterogeneity, which makes them challenging to treat, the early stages of cancer are less complex, providing an opportunity for more effective interventions. The Kübler lab studies the genomic changes and molecular mechanisms that drive early cancer development. To this end, the lab develops and applies new computational and experimental genomic techniques. A better understanding of the processes underlying cancer initiation and progression will ultimately help enable early intervention and improve patient outcomes.

For more information, please visit https://kueblerlab.org/

 

Group members

See our lab website at https://kueblerlab.org/

Selected References

• Gopal, R.K.*, Kübler, K.*, Calvo, S.E., Polak, P., Livitz, D., Rosebrock, D., Sadow, P.M., Campbell, B., Donovan, S.E., Amin, S., Gigliotti, B.J., Grabarek, Z., Hess, J.M., Stewart, C., Braunstein, L.Z., Arndt, P.F., Mordecai, S., Shih, A.R., Chaves, F., Zhan, T., Lubitz, C.C., Kim, J., Iafrate, A.J., Wirth, L., Parangi, S., Leshchiner, I., Daniels, G.H., Mootha, V.K., Dias-Santagata, D., Getz, G., McFadden, D.G."Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma." Cancer Cell 2018; 34(2):242-255.e5. doi: 10.1016/j.ccell.2018.06.013 (*, contributed equally, listed in alphabetical order)
• Machado, H.E., Mitchell, E.*, Øbro, N.F.*, Kübler, K.*, Davies, M., Leongamornlert, D., Cull, A., Maura, F., Sanders, M.A., Cagan, A.T.J., McDonald, C., Belmonte, M., Shepherd, M.S., Vieira Braga, F.A., Osborne, R.J., Mahbubani, K., Martincorena, I, Laurenti, E., Green, A.R., Getz, G., Polak, P., Saeb-Parsy, K., Hodson, D.J., Kent, D.G., Campbell, P.J. (2022)  "Diverse mutational landscapes in human lymphocytes." Nature. Aug;608(7924):724-732. doi: 10.1038/s41586-022-05072-7 (*, contributed equally)
• Yizhak, K., Aguet, F., Kim, J., Hess, J.M., Kübler, K., Grimsby, J., Frazer, R., Zhang, H., Haradhvala, N.J., Rosebrock, D., Livitz, D., Li, X., Arich-Landkof, E., Shoresh, N., Stewart, C., Segrè, A.V., Branton, P.A., Polak, P., Ardlie, K.G., Getz, G.(2019)  "RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues." Science. 2019; 364: 6444. doi: 10.1126/science.aaw0726
• Kübler, K.*, Karlic, R.* Haradhvala, N.J., Ha, K., Kim, J., Kuzman, M., Jiao, W., Gakkhar, S., Mouw, K.W., Braunstein, L.Z., Elemento, O., Biankin, A.O., Rooman, I., Miller, M., Karthaus, W.R., Nogiec, C.D., Juvenson, E., Curry, E., Mino-Kenudson, M., Ellisen, L.W., Brown, R., Gusev, A., Tomasetti, C., Lolkema, M.P., Steeghs, N., van Herpen, C., Kim, H-G., Lee, H., Vlahovicek, K., Bernstein, B.E., Sawyers, C.L., Hoadley, K.A., Cuppen, E., Koren, A., Arndt, P.F., Louis, D.N., Stein, L.D., Foulkes, W.D., Polak, P., Getz, G. on behalf of the PCAWG Pathology and Clinical Correlates Working Group, and the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network. (2019) "Tumor mutational landscape is a record of the pre-malignant state."  bioRxiv, doi.org/10.1101/517565 (*, contributed equally)
• Polak, P., Kim, J., Braunstein, L.Z., Karlic, R., Haradhavala, N.J., Tiao, G., Rosebrock, D., Livitz, D., Kübler, K., Mouw, K.W., Kamburov, A., Maruvka, Y.E., Leshchiner, I., Lander, E.S., Golub, T.R., Zick, A., Orthwein, A., Lawrence, M.S., Batra, R.N., Caldas, C., Haber, D.A., Laird, P.W., Shen, H., Ellisen, L.W., D'Andrea, A.D., Chanock, S.J., Foulkes, W.D., Getz, G.(2017) "A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer." Nature Genetics; 49(10):1476-1486 doi: 10.1038/ng.3934