Dr. rer. nat. Leif Schröder

Research Group Leader, Molecular Imaging, Leibniz-Forschungsinstitut für Molekulare
Pharmakologie (FMP)

Brief CV & Research focus

University Education

  • 2001 Diploma in Physics, Universität Heidelberg
  • 2003 Dr. rer. nat., Universität Heidelberg
  • 2005 Emmy Noether Fellow, University of California at Bekeley
  • 2007 Postdoctoral Fellow, Lawrence Berkeley National Laboratory

Professional Experience (selection)

  • 2009- Head of the Emmy Noether-Group Molecular Imaging, FMP
  • 2009-2014 Head of the ERC Project BiosensorImaging, FMP
  • 2017 Head of the Koselleck Project "MRI Visualization of Tumor Cell Surface Glycans"

Research Fields

  • i)   Main field: NMR Spectroscopy and imaging
  • ii)  Current research interest: Hyperpolarised biosensors for NMR and MRI

Scientific Scope and Goals

  • Hyperpolarized contrast agents
  • Molecular imaging
  • NMR and MRI methodology
  • Contrast agent synthesis

Our group works on the development of novel magnetic resonance reporters and the related detection techniques for diagnostic imaging and spectroscopy. Xenon biosensors have an outstanding potential to increase the significance of magnetic resonance imaging (MRI) in molecular diagnostics. To explore this potential, our group could repeatedly obtain support through programs focusing on highly innovative approaches, including the Koselleck Program of the DFG and the European Research Council (ERC). 

Most important Awards, Grants or Scientififc Achievements

  • Founding member of the Young Academy of Europe
  • 2009 Emmy Noether Fellow of the German Research Foundation
  • 2009 Young Scientist Prize of trhe International Union for Pure and Applied Physics
  • 2008 Dr. Emil Salzer Prize for Cancer Research of the German Cancer Research Center
  • 2007 Gorter Award of the German Chapter of the International Society for Magnetic Resonance in Medicine
  • 2005 Philips Research Prize for Medical Physics

Most important recent Publications

  • Lakshmanan, A., Lu, G.L., Farhadi, A., Nety, S. P., Kunth, M., Lee-Gosselin, A., Maresca, D., Bourdeau, R.W., Yin, M., Yan, J., Witte, C., Foster, F. S., Schröder, L., Shapiro, M. G. Preparation and Noninvasive Imaging of Biogenic Gas Vesicle Nanostructures. Nature Protocols 2017; 12(10): 2050-2080
  • Piontek, A., Witte, C., May Rose, H., Eichner, M., Protze, J., Krause, G., Piontek, J. and Schröder, L. A cCPE-based xenon biosensor for magnetic resonance imaging of claudin-expressing cells. Ann. N.Y. Acad. Sci. 2017; 1397: 195–208.
  • Kunth, M., Witte, C., Hennig, A., Schröder, L. Identification, Classification, and Signal Amplification Capabilities of High-Turnover Gas Binding Hosts in Ultra-Sensitive NMR (highlighted as cover article). Chem. Sci. 2015; 6: 6069-6075
  • Klippel, S., Freund, C., Schröder, L. Multi-Channel MRI Labeling of Mammalian Cells by Switchable Nanocarriers for Hyperpolarized Xenon (highlighted as cover article). Nano Lett. 2014; 14(10): 5721-5726

Most relevant Publications

  • Witte, C., Martos, V., Rose, H. M., Reinke S., Klippel, S., Schröder, L., Hackenberger, C. P. R. Live-cell MRI of xenon Hyper-CEST biosensors targeted to metabolically-labeled cell-surface glycans (highlighted as cover article). Angew. Chem. Int. Ed. 2015; 54: 2806-2810
  • Rose, H. M., Witte, C., Rossella, F., Klippel, S., Freund, C., Schröder, L. Development of an Antibody-Based, Modular Biosensor for 129Xe NMR Molecular Imaging of Cells at Nanomolar Concentrations. Proc. Natl. Acad. Sci. U.S.A. 2014; 111(32): 11697-11702
  • Weber, M. A., Krakowski-Roosen, H., Schröder, L., Kinscherf, R., Krix, M., Kopp-Schneider, A., Essig, M., Bachert, P., Kauczor, H.U., Hildebrandt, W. Morphology, metabolism, microcirculation, and strength of skeletal muscles in cancer-related cachexia. Acta Oncol. 2009; 48: 116-124
  • Schröder, L., Lowery, T. J., Hilty, C., Wemmer, D. E., and Pines, A. Molecular imaging using a hyperpolarized xenon biosensor (highlighted as editor’s choice and by a Science Perspective article). Science 2006; 314: 446-449.