Dr. Sascha Sauer

Scientific Genomics Platforms
Laboratory of Functional Genomics, Nutrigenomics and Systems Biology
Max-Delbrück Center for Molecular Medicine (MDC)
Berlin Institute for Medical Systems Biology (BIMSB)
Berlin Institutes of Health (BIH)
Hannoversche Str. 28
10115 Berlin
Germany

Tel: +49 (0) 30 9406 2995
Email: sascha.sauer(at)mdc-berlin.de
https://genomics.mdc-berlin.de/

Scientific Scope

We aim to explore fundamental biological phenomena and to pursue innovative approaches for translating new insights to eventually help the patient. The main focus of our group lies on functional genome research using sophisticated next generation sequencing and in particular single-cell genomics methodologies. Current key activities comprise basic research-oriented functional genomics research projects (e.g. gene-regulatory mechanisms and epigenetic phenomena), as well as medically relevant projects (e.g. single-cell DNA and RNA analyses of tumors).

Future Directions

By developing and using newest analytical tools, we aim to develop efficient diagnostic and treatment options tailored to combat patient-specific cellular heterogeneity of tumors.

Selected References

  • Fischer C, Metsger M, Bauch S, Vidal R, Böttcher M, Grote P, Kliem M, Sauer S. Signals trigger state-specific transcriptional programs to support diversity and homeostasis in immune cells. Science Signal. 2019 May 14;12(581). pii: eaao5820. 
  • Zhu Q, Fang L, Heuberger J, Kranz A, Schipper J, Scheckenbach K, Vidal RO, Sunaga-Franze DY, Müller M, Wulf-Goldenberg A, Sauer S, Birchmeier W. The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer. Cell Rep. 2019 Jan 8;26(2):415-428.e5.
  • Schubert M, Klinger B, Klünemann M, Sieber A, Uhlitz F, Sauer S, Garnett MJ, Blüthgen N, Saez-Rodriguez J. Perturbation-response genes reveal signaling footprints in cancer gene expression. Nature Commun. 2018 Jan 2;9(1):20.
  • Pei W, Feyerabend TB, Rössler J, Wang X, Postrach D, Busch K, Rode I, Klapproth K, Dietlein N, Quedenau C, Chen W, Sauer S, Wolf S, Höfer T, Rodewald HR. Polylox barcoding reveals haematopoietic stem cell fates realized in vivo. Nature. 2017 Aug 24;548(7668):456-460. 
  • Plauth A, Geikowski A, Cichon S, Wowro SJ, Liedgens L, Rousseau M, Weidner C, Fuhr L, Kliem M, Jenkins G, Lotito S, Wainwright LJ, Sauer S. Hormetic shifting of redox environment by pro-oxidative resveratrol protects cells against stress. Free Radic Biol Med. 2016 Oct;99:608-622.