Prof. Dr. med. Frederik Damm
Research Group Leader
Department of Hematology, Oncology, and Tumor Immunology
Charité - Universitätsmedizin Berlin
Augustenburgr Platz 1
13353 Berlin
E-Mail: frederik.damm(at)charite.de
https://haema-onko-cvk.charite.de/forschung/arbeitsgruppen/ag_damm/
Scientific Scope
The research group of Frederik Damm focuses on genetic events defining early steps during leukemo-/ lymphomagenesis using several molecular biology techniques. Combinations of various sequencing technologies using bulk and single-cell approaches help to develop novel models of precision oncology. A broad national and international collaborating network supports investigations of rare tumor entities and/or molecularly defined subgroups.
Selected References
- Mylonas, E., Yoshida, K., Frick, M., Hoyer, K., Christen, F., Kaeda, J., Obenaus, M., Noerenberg, D., Hennch, C., Chan, W., Ochi, Y., Shiraishi, Y., Shiozawa, Y., Zenz, T., Oakes, C. C., Sawitzki, B., Schwarz, M., Bullinger, L., le Coutre, P., Rose-Zerilli, M., … Damm, F. (2020) "Single-cell analysis based dissection of clonality in myelofibrosis." Nature communications, 11(1), 73.
- Christen, F., Hoyer, K., Yoshida, K., Hou, H. A., Waldhueter, N., Heuser, M., Hills, R. K., Chan, W., Hablesreiter, R., Blau, O., Ochi, Y., Klement, P., Chou, W. C., Blau, I. W., Tang, J. L., Zemojtel, T., Shiraishi, Y., Shiozawa, Y., Thol, F., Ganser, A., … Damm, F. (2019) "Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): an international study on 331 patients." Blood, 133(10), 1140–1151.
- Frick, M., Chan, W., Arends, C. M., Hablesreiter, R., Halik, A., Heuser, M., Michonneau, D., Blau, O., Hoyer, K., Christen, F., Galan-Sousa, J., Noerenberg, D., Wais, V., Stadler, M., Yoshida, K., Schetelig, J., Schuler, E., Thol, F., Clappier, E., Christopeit, M., … Damm, F. (2019) "Role of Donor Clonal Hematopoiesis in Allogeneic Hematopoietic Stem-Cell Transplantation." Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 37(5), 375–385.
- Arends, C. M., Galan-Sousa, J., Hoyer, K., Chan, W., Jäger, M., Yoshida, K., Seemann, R., Noerenberg, D., Waldhueter, N., Fleischer-Notter, H., Christen, F., Schmitt, C. A., Dörken, B., Pelzer, U., Sinn, M., Zemojtel, T., Ogawa, S., Märdian, S., Schreiber, A., Kunitz, A., … Damm, F. (2018) "Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis." Leukemia, 32(9), 1908–1919.
- Damm, F., Mylonas, E., Cosson, A., Yoshida, K., Della Valle, V., Mouly, E., Diop, M., Scourzic, L., Shiraishi, Y., Chiba, K., Tanaka, H., Miyano, S., Kikushige, Y., Davi, F., Lambert, J., Gautheret, D., Merle-Béral, H., Sutton, L., Dessen, P., Solary, E., … Bernard, O. A. (2014) "Acquired initiating mutations in early hematopoietic cells of CLL patients." Cancer discovery, 4(9), 1088–1101.