PD Dr. med. Frederik Damm

Research Group Leader
Department of Hematology, Oncology, and Tumor Immunology
Charité - Universitätsmedizin Berlin
Augustenburgr Platz 1
13353 Berlin

E-Mail: frederik.damm(at)charite.de
https://haema-onko-cvk.charite.de/forschung/arbeitsgruppen/ag_damm/

Scientific Scope

The research group of Frederik Damm focuses on genetic events defining early steps during leukemo-/ lymphomagenesis using several molecular biology techniques. Combinations of various sequencing technologies using bulk and single-cell approaches help to develop novel models of precision oncology.  A broad national and international collaborating network supports investigations of rare tumor entities and/or molecularly defined subgroups.

Selected References

  • Christen F, Hoyer K, Yoshida K, ..., Damm F. Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): an international study on 331 patients. Blood (Published online January 04, 2019; Epub ahead of print). doi: 10.1182/blood-2018-05-852822 
  • Frick M, Chan W, Arends CM, ..., Damm F. Role of Donor Clonal Hematopoiesis in Allogeneic Hematopoietic Stem-Cell Transplantation. Journal of Clinical Oncology (Published online November 07, 2018). doi: 10.1200/JCO.2018.79.2184 
  • Arends CM, Galan-Sousa J, Hoyer K, …, Damm F. Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis. Leukemia (2018). doi:10.1038/s41375-018-0047-7 
  • Young E, Noerenberg D, Mansouri L, ..., Damm F. EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia. Leukemia 31, 1547–1554 (2017). doi:10.1038/leu.2016.359
  • Mansouri L, Noerenberg D, Young E, ..., Damm F. Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma. Blood 128, 2666–2670 (2016). doi:10.1182/blood-2016-03-704528