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  4. PD Dr. med. Matthäus Felsenstein

PD Dr. med. Matthäus Felsenstein

Chirurgische Klinik | Experimentelle Chirurgie

Charité – Universitätsmedizin Berlin
Campus Charité Mitte | Campus Virchow-Klinikum

Augustenburger Platz 1 | 13353 Berlin

Telefon +49 30 450  652 465

Scientific Scope

Modern academic and clinical surgery increasingly demands a fundamental understanding of the individual’s tumor biology. State-of-the art oncologic research paves the way for in-depth characterization and investigation of molecular signatures responsible for carcinoma development. The focus of the Molecular Carcinogenesis Lab is to investigate the genomic determinants responsible for pancreato-biliary tumor initiation and progression. This process regularly involves the tumors microenvironment and is of major interest as well. We use modern tools like Next-Generation Sequencing, single-cell transcriptomics, genome engineering, three-dimensional tissue culture  and assays for immune modulation to address basic- and translational research questions around pancreato-biliary carcinogenesis.

Group Members

Isis Lozzi Da Costa, Cand. Dr. med. – Dissertation (eingereicht 07/24, Erst-Betreuer)

Mengwen Hu, Cand. Dr. med.  – Dissertation in Prozess (erwartete Einreichung 2024) (Erst-Betreuer)

Ruonan Wang, Cand. Dr. med.  – Dissertation in Prozess (erwartete Einreichung 2024, Erst-Betreuer)

Ann-Christin Amini, Cand. Dr. med. – Dissertation in Prozess (erwartete Einreichung 2024, Erst-Betreuer)

Cao Zhong Jin, Cand. Dr. med. – aktuell Datenakquirierung (Erst-Betreuer)

Jenny Tamboli, M.Sc. Bioinformatik, Cand. PhD – aktuell Datenakquirierung (Erst-Betreuer)

Sophie Dorfer, Cand. Dr. med.  – aktuell Datenakquirierung (Erst-Betreuer)

Dou Ma, Cand. Dr. med.  – aktuell Datenakquirierung (Erst-Betreuer)

Pedro Pereira, Cand. Dr. med.  – aktuell Datenakquirierung (Erst-Betreuer)

Josephine Grandi, Cand. Dr. med. – Beginn Datenakquirierung (Erst-Betreuer)

 

Most important Awards, Grants or Scientific Achievements:

Awards:                                    
Title                                Admission to the German Excellence Academy          
Event                             Konvent of academic direrectors for General- and Visceral surgery 2024
Institution                   Deutsche Gesellschaft für Allgemeinchirurgie (DGAV)

Title                                Sol Goldman Research Fellow Award       
Event                              Annual Award Ceremony / Department of Pathology 2018
Institution                   Johns Hopkins University School of Medicine / Baltimore (USA)

Grants:                                  
Program                        Research grant    
Institution                    Else Kröner Fresenius Stiftung (EKFS)
Period                            04/2023 – 03/2026                             
Reference                     2022_EKEA.74

Program                        Clinician Scientist Program      
Institution                    Berlin Institute of Health (BIH)
Period                            01/2022 – 12/2024  
Reference                     https://www.bihealth.org/   

Program                        Starting Grant Berliner Krebsgesellschaft
Institution                    Berliner Krebsgesellschaft (BKG)
Period                            05/2021 – 04/2022
Reference                     FEFF202108

Program                        Research grant
Institution                    Deutsche Forschungsgemeinschaft (DFG)
Period                            01/2018 – 12/2018
Reference                     FE-1747/1-1

Program                        Research Award Fellowship
Institution                    Sol Goldman Pancreatic Cancer Research Foundation
Period                            01/2017 – 12/2017
Reference                     http://pathology.jhu.edu/pc/goldmancenter/awardees2017.cfm

 

 

 

 

 

Selected References

  • Cytokine-armed vaccinia virus promotes cytotoxicity towards pancreatic carcinoma cells via activation of human intermediary CD56dimCD16dim natural killer cells. Wang R, Hu M, Lozzi I, Jin CZJ, Ma D, Splith K, Mengwasser J, Wolf V, Feldbrügge L, Tang P, Timmermann L, Hillebrandt KH, Kirchner M, Mertins P, Hilfenhaus G, Neumann C, Kammertoens T, Pratschke J, Malinka T, Sauer I, Nössner E, Guo Z, Felsenstein M. Int J Cancer. 2024. PMID: 39400317
  • Clinical prognosticators and targets in the immune microenvironment of intrahepatic cholangiocarcinoma. Lozzi I, Arnold A, Barone M, Johnson JC, Sinn BV, Eschrich J, Gebert P, Wang R, Hu M, Feldbrügge L, Schirmeier A, Reutzel-Selke A, Malinka T, Krenzien F, Schöning W, Modest DP, Pratschke J, Sauer IM, Felsenstein M. Oncoimmunology. 2024. PMID: 39359389
  • Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions. Fujikura K*, Hosoda W*, Felsenstein M*, Song Q, Reiter JG, Zheng L, Beleva Guthrie V, Rincon N, Dal Molin M, Dudley J, Cohen JD, Wang P, Fischer CG, Braxton AM, Noë M, Jongepier M, Fernández-Del Castillo C, Mino-Kenudson M, Schmidt CM, Yip-Schneider MT, Lawlor RT, Salvia R, Roberts NJ, Thompson ED, Karchin R, Lennon AM, Jiao Y, Wood LD. Gut. 2020; PMID: 33028669   

           *Authors contributed equally

  • Generation and characterization of a cell line from an intraductal tubulopapillary neoplasm of the pancreas. Felsenstein M, Trujillo MA, Huang B, Nanda N, Jiang Z, Jeong YJ, Pflüger M, Goggins MG, Hruban RH, Thompson ED, Heaphy CM, Roberts NJ, Wood LD. Lab Invest. 2020; PMID: 32005909
  • IPMNs with co-occurring invasive cancers: neighbours but not always relatives. Felsenstein M, Noë M, Masica DL, Hosoda W, Chianchiano P, Fischer CG, Lionheart G, Brosens LAA, Pea A, Yu J, Gemenetzis G, Groot VP, Makary MA, He J, Weiss MJ, Cameron JL, Wolfgang CL, Hruban RH, Roberts NJ, Karchin R, Goggins MG, Wood LD. Gut 2018; PMID: 29500184