Prof. Dr. med. Britta Siegmund

AG Siegmund
Charité - Universitätsmedizin Berlin
Division of Gastroenterology, Infectiology and Rheumatology
Hindenburgdamm 30
12200 Berlin
Tel: +49 30 450 514 322 (Secretary)

E-Mail: britta.siegmund(at)charite.de
https://gastro.charite.de/forschung/ag_siegmund/

Scientific Scope

In the tumor microenvironment, the metabolic milieu differs tremendously from healthy tissue. Glycolysis and fatty acid oxidation are out of balance; you find ongoing hypoxia, inflammation and regeneration. In our previous and recent studies, we see a clear effect of unsaturated fatty acids like oleic acid on the functional polarization of myeloid cells into a monocytic MDSC- as well as a TAM-like phenotype. We could also link this phenotype directly to the formation of lipid droplets inside these cells and an increased fatty acid oxidation compared to control groups. To discover the metabolic pathways and switches to modulate myeloid cell phenotypes in the context of tumor but also intestinal inflammation is one of our major projects in the group.

Selected References

  • Schmidt F, Dahlke K, Batra A, Keye J, Wu H, Friedrich M, Glauben R, Ring C, Loh G, Schaubeck M, Hackl H, Trajanoski Z, Schumann M, Kühl AA, Blaut M, Siegmund B. Microbial Colonization in Adulthood Shapes the Intestinal Macrophage Compartment. J Crohns Colitis. 2019 Apr 1. pii: jjz036. doi:10.1093/ecco-jcc/jjz036. [Epub ahead of print]
  • Wu H, Weidinger C, Schmidt F, Keye J, Friedrich M, Yerinde C, Willimsky G, Qin Z, Siegmund B, Glauben R. Oleate but not stearate induces the regulatory phenotype of myeloid suppressor cells. Sci Rep. 2017 Aug 8;7(1):7498. doi: 10.1038/s41598-017-07685-9.
  • Xu X, Meng Q, Erben U, Wang P, Glauben R, Kühl AA, Wu H, Ma CW, Hu M, Wang Y, Sun W, Jia J, Wu X, Chen W, Siegmund B, Qin Z. Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner. Cell Mol Immunol. 2017 Jul;14(7):597-606. doi: 0.1038/cmi.2015.103. Epub 2016 May 2.
  • Lissner D, Schumann M, Batra A, Kredel LI, Kühl AA, Erben U, May C, Schulzke JD, Siegmund B. Monocyte and M1 Macrophage-induced Barrier Defect Contributes to Chronic Intestinal Inflammation in IBD. Inflamm Bowel Dis. 2015 Jun;21(6):1297-305. doi: 10.1097/MIB.0000000000000384.
  • Kredel LI, Batra A, Stroh T, Kühl AA, Zeitz M, Erben U, Siegmund B. Adipokines from local fat cells shape the macrophage compartment of the creeping fat in Crohn's disease. Gut. 2013 Jun;62(6):852-62. doi: 10.1136/gutjnl-2011-301424. Epub 2012 Apr 28.