Prof. Dr. med. Frank Heppner

Research Group “Neurodegenerative Diseases”
Department of Neuropathology, Charité - Universitätsmedizin Berlin
Charitéplatz 1
D-10117 Berlin
Germany
Tel: +49-30-450536041

E-mail: frank.heppner(at)charite.de
https://neuropathologie.charite.de/en/research/neurodegenerative_diseases/

Scientific Scope

The research group is active in the field of experimental and translational neuropathology & neuroscience focusing on immunological aspects of neurological disorders such as neurodegenerative diseases, mechanisms of immunotherapeutic approaches, impact of neuroinflammation on systemic metabolism and biology of microglia.

Most important Awards, Grants or Scientific Achievements

  • 2003 Pfizer-Award for Neurosciences and Diseases of the Nervous System, Switzerland
  • 2003 Research fellowship of the Leopoldina-Foundation
  • 2006 Siegenthaler-Habilitation Award, Universität Zürich, Switzerland
  • 2010 Spokesman of the SFB TRR 43 "The brain as a target of inflammatory processes"

Selected References

  • Houtman J, Freitag K, Gimber N, Schmoranzer J, Heppner FL*, Jendrach M*. Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3. EMBO J 2019 Feb 15;38(4). doi: 10.15252/embj.201899430. (*shared senior authorship)

  • Kälin S, Miller KR, Kälin RE, Jendrach M, Witzel C, Heppner FL. CNS myeloid cells critically regulate heat hyperalgesia. J Clin Invest 2018 Jul 2;128(7):2774-2786. doi: 10.1172/JCI95305.

  • Prokop S, Miller KR, Drost N, Handrick S, Mathur V, Luo J, Wegner A, Wyss Coray T, Heppner FL. Impact of peripheral myeloid cells on amyloid-beta pathology in Alzheimer’s disease-like mice. J Exp Med 2015 Oct 19:212 (11):1811-1818. doi:10.1084/jem.20150479.

  • Vom Berg J, Prokop S, Miller KR, Obst J, Kälin RE, Lopategui-Cabezas I, Wegner A, Mair F, Schipke CG, Peters O, Winter Y, Becher B, Heppner FL. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Nat Med 2012 Dec;18(12):1812-9. doi: 10.1038/nm.2965.

  • Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL*, Jucker M*. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci 2009 Nov;12(11):1361-3. doi: 10.1038/nn.2432. (*shared senior authorship)

  • Falsig J, Julius C, Margalith I, Schwarz P, Heppner FL, Aguzzi A. A versatile prion replication assay in organotypic brain slices. Nat Neurosci 2008 Jan;11(1):109-17. doi: 10.1038/nn2028.

  • Heppner FL, Greter M, Marino D, Falsig J, Raivich G, Hövelmeyer N, Waisman A, Rülicke T, Prinz M,  Priller J, Becher B, Aguzzi A. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med  2005 Feb;11(2):146-52. doi: 10.1038/nm1177.

  • Greter M, Heppner FL, Durell B, Lemos MP, Odermatt BM, Goebels N, Laufer T, Noelle RJ, Becher B. Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nat Med 2005 Mar;11(3):328-34. doi: 10.1038/nm1197.

  • Heppner FL, Christ AD, Klein MA, Prinz M, Fried M, Kraehenbuhl JP, Aguzzi A. Transepithelial prion transport by M cells. Nat Med 2001 Sep;7(9):976-7. doi: 10.1038/nm0901-976.