Department of Hematology, Oncology and Tumorimmunology
Charité Universitätsmedizin Berlin
Campus Benjamin Franklin
Phone: +49 030 450 613 564
- 1999 -2006 Medical School, Ruprecht-Karls-University Heidelberg, Germany
- 2006-2015 Resident/Research fellow in Internal Medicine and Hematology/Oncology at the Department of Internal Medicine III, University Hospital Ulm
- 2011-2014 Research Fellow at the Brigham and Women's Hospital/Harvard Medical School, Laboratory of Prof. Dr. Benjamin L. Ebert, MD/PhD (DFG Research fellowship)
- 2015 Emmy Noether Reseach Group Leader (DFG)
- 2020 Professorship/Attending for Hematology, Charité Berlin
- SFB 1074 member
- Emmy-Noether Research Group Leader
- Paul-Martini Award
- Artur Pappenheim award
- Franziska-Kolb award for Leukemia research
The ubiquitin-proteasome-system is an essential cellular pathway that regulates stability and function of proteins. In cancer cells ubiquitination is frequently deregulated by mutation or aberrant expression of ubiquitin ligases and deubiquitinating enzymes. Moreover, recently we and others found that drugs like thalidomide analogs hijack ubiquitin ligases to rapidly degrade cancer-related proteins including those that were previously considered undruggable such as transcription factors. The focus of our research is to determine the impact of deregulated protein ubiquitination and protein stability in hematologic malignancies. We apply comprehensive proteomic and genetic analyses in primary patient samples combined with CRISPR/Cas9 functional genetics to uncover disease driving and resistance mediating alterations in the ubiquitin-proteasome system. In addition, we study new compounds like proteolysis-targeting chimeras (PROTACs) that direct ubiquitin ligases to proteins as targeted treatments for cancer. The ultimate goal is to translate our findings into the clinic for personalized treatments.
- Dora Ng (Charité)
- Dr. Evelyn Ramberger (Charité)
- Thomas Kallweit (Charité)
- Mina Jamali (Charité)
- Linda Röhner (Ulm University)
- Dr. Xiang Gao (Ulm University)
- Sirui Chen (Ulm University)
- Johannes Steinhart (Ulm University)
- Steinebach C, Ng D, Sosič I, Lee C, Chen S, Lindner S, Vu L, Bricelj A, Haschemi R, Monschke M, Steinwarz E, Wagner KG, Bendas G, Luo J, Gütschow M, Krönke J. Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders. Chemical Science. 2020; 11(13): 3474-3486
- Meyer T, Jahn N, Lindner S, Röhner L, Dolnik A, Weber D, Scheffold A, Köpff S, Paschka P, Gaidzik VI, Heckl D, Wiese S, Ebert BL, Döhner H, Bullinger L, Döhner K, Krönke J. Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1). Leukemia. 2020 Feb;34(2):404-415.
- Krönke J*, Fink E*, Hollenbach P, MacBeth K, Hurst S, Udeshi N, Chamberlain P, Mani D, Man H, Gandhi A, Svinkina T, Schneider R, McConkey M, Järås M, Griffiths E, Wetzler M, Bullinger L, Cathers B, Carr S, Chopra R, Ebert B. Lenalidomide induces ubiquitination and degradation of casein kinase 1A1 in del(5q) MDS. Nature. 2015;523(7559):183-8. *Equal contribution.
- Krönke J, Udeshi ND, Narla A, Grauman P, Hurst SN, McConkey M, Svinkina T, Heckl D, Comer E, Li X, Ciarlo C, Hartman E, Munshi N, Schenone M, Schreiber SL, Carr SA, Ebert BL. Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science. 2014;343(6168):301-5.
- Krönke J, Bullinger L, Teleanu V, Tschürtz F, Gaidzik VI, Kühn MW, Rücker FG, Holzmann K, Paschka P, Kapp-Schwörer S, Späth D, Kindler T, Schittenhelm M, Krauter J, Ganser A, Göhring G, Schlegelberger B, Schlenk RF, Döhner H, Döhner K. Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia. Blood. 2013;122(1):100-8.
- Krönke J, Schlenk RF, Jensen KO, Tschürtz F, Corbacioglu A, Gaidzik VI, Paschka P, Onken S, Eiwen K, Habdank M, Späth D, Lübbert M, Wattad M, Kindler T, Salih HR, Held G, Nachbaur D, von Lilienfeld-Toal M, Germing U, Haase D, Mergenthaler HG, Krauter J, Ganser A, Göhring G, Schlegelberger B, Döhner H, Döhner K. Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: a study from the German-Austrian acute myeloid leukemia study group. J Clin Oncol. 2011;29(19):2709-16.