Prof. Dr. med. Nikolaus Rajewsky

Director of the Berlin Institute for Medical Systems Biology (BIMSB)
Max-Delbrück Center for Molecular Biology (MDC)
Hannoversche Str. 28
10115 Berlin
Germany

www.mdc-berlin.de/rajewsky

Scientific Scope

The PhD candidate would apply our single-cell gene expression analysis methods (Karaiskos et al Science 2017, Plass et al Science 2018) to understand heterogeneity and the role of cancer stem cells in tumorigenesis. We are currently developing three-dimensional RNA sequencing of solid tumors and the PhD candidate would be able to generate and interpret these data in patient’s biopsies, thus possibly helping to develop novel diagnosis and therapy strategies. Skillset: molecular biology OR biochemistry OR computer science OR bioinformatics. We are a multidisciplinary team. Our work was featured in Science’s “Breakthrough of the year 2018”.

Most important Awards, Grants or Scientific Achievements

  • 2010 Member of the International Advisory Committee for SISSA (Trieste); Elected EMBO Member; “Berliner Wissenschaftspreis”
  • 2008- Global Distinguished Professor of Biology at New York University
  • 2008 First prize from the „Deutsche Gesellschaft für Gentherapie“ for the best paper; Anniversary Price of the German Society for Biochemistry, awarded by FEBS; IUBMB (International Union for Biochemistry and Molecular Biology): Medal for outstanding contributions

Selected References

  • Plass, M, Solana, J, Wolf, FA, Ayoub, FA, Misios, A, Glazar, P, Obermayer, B, Theis, FJ, Kocks, C, Rajewsky, N. (2018) Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics. Science 360 (6391).
  • Karaiskos, N, Wahle, P, Alles, J, Boltenhagen, A, Ayoub, S, Kipar, C, Kocks, C, Rajewsky, N, Zinzen, RP. (2017) The Drosophila at single-ceöö transcriptome resolution. Science 358 (6360), 194-199.
  • Adamidi C, …,  Rajewsky N, Wei C (2011), De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics. Genome Res.
  • Friedländer MR, …, Rajewsky N (2008) miRDeep: discovering miRNAs from deep sequencing data. Nature Biotechnol. 26, 407-415.
  • Selbach M, …, Rajewsky N (2008) Widespread changes in protein synthesis induced by microRNAs. Nature 455(7209), 58-63.