Prof. Dr. med. Winfried Brenner

Department of Nuclear Medicine
Department of Nuclear Medicine and Berlin Experimental Radionuclide Imaging Center (BERIC)
Charité - Universitätsmedizin Berlin
Augustenburger Platz 1
13353 Berlin
Germany
Tel: +49 30 450 527 051
Fax: +49 30 450 7 527 051

E-Mail: Winfried.brenner(at)charite.de
https://nuklearmedizin.charite.de/

University Education

  • 1992 M.D., state examination, Universitätsmedizin Ulm
  • 2002 Habilitation in Nuclear Medicine, Universitätsklinikum Kiel

Professional Experience (selection)

  • 1992-1998 Physician and Research Assistant, Department of Nuclear Medicine, Universitätsklinikum Kiel
  • 1998-2002 Assistant Director, Department of Nuclear Medicine, Universitätsklinikum Kiel
  • 2002-2004 Visiting Assistant Professor, University of Washington, USA
  • 2004-2009 Professor of Nuclear Medicine (C3), Director PET/CT, Department of Nuclear Medicine, Universitätsklinikum Hamburg-Eppendorf
  • 2009- present Head of the Department of Nuclear Medicine, Charité

Scientific Scope

Our primary aims are:

  1. Development and in-vivo testing of new radioactive labeled pharmaceuticals for diagnosis and/or treatment of cancer on a preclinical and clinical scale
  1. Development of new or improved quantitative multimodal imaging approaches including SPECT, PET, CT and MRI for tumor characterization, biokinetic modeling, radiomics and texture analysis including deep learning approaches
  1. Use of multifunctional imaging procedures as an additional tool for all groups working on in-vivo studies in cancer research in men, mice, CAM, and organoids

So our research within BSIO comprises oncology, (radio)chemistry, and quantitative imaging/physics/radiomics/kinetic modeling.

PET/MRI: in vivo imaging of a tumor bearing mouse (fused angiography with GadoSpinP MRI and F-18-FDG PET)

Group Members

Dr. Sarah Spreckelmeyer – Radiochemist
Dr. Sonal Prasad – Radiochemist, cell cultures
Dr. Nicola Beindorff – veterinarian, board-certified in laboratory animal science
Ajay Mohan, PhD student

Selected References

  • Koziolek E. J., Briest F., Exner S., Sedding D., Groetzinger C., Grabowski P. Brenner W. A BON-SSTR2 chicken chorioallantoic membrane (CAM) model and imaging portfolio for the analysis of Lu-177-DOTATOC therapeutic effect and sensitizing agents. (EMIM 2018 Poster Award, Category: New tools for cancer imaging)
  • Gomez JDC, Hagenbach A, Gerling-Driessen UIM, Koksch B, Beindorff N, Brenner W, Abram U. Thiourea de-rivatives as chelating agents for bioconjugation of rhenium and technetium. Dalton Trans. 46:14602-14611(2017)
  • Beindorff N, Bartelheimer A, Huang K, Lukas M, Lange C, Huang EL, Aschenbach JR, Eary JF, Steffen IG, Brenner W. Normal Values of Thyroid Uptake of 99mTechnetium Pertechnetate SPECT in Mice with Respect to Age, Sex, and Circadian Rhythm. Nuklearmedizin. 2018, 57(5):181-189.
  • Albrecht J, Polenz D, Kühl AA, Rogasch JMM, Leder A, Sauer IM, Babos M, Mocsai G, Beindorff N, Steffen IG, Brenner W, Koziolek EJ. Diffusion-weighted magnetic resonance imaging using a preclinical 1 T PET/MRI in healthy and tumor-bearing rats. EJNMMI Res (2019) 9: 21. https://doi.org/10.1186/s13550-019-0489-6
  • Von Hacht J.L., Erdmann S., Niederstadt L., Prasad S., Wagener A., Exner S., Beindorff N., Brenner W., Groetzinger C. Increasing molar activity by HPLC purification improves 68Ga-DOTA-NAPamide tumor accumulation in a B16/F1 melanoma xenograft model. PLos ONE, 2019, in print.