Prof. Dr. rer. nat. Christoph Arenz

Organic and Bioorganic Chemistry
Humbold-Universität zu Berlin
Institut für Chemie
Brook-Taylor-Str. 2 (R1'102)
12489 Berlin
Tel: +49 30 2093 8393
Fax: +49 30 2093 6947

E-Mail: christoph.arenz(at)chemie.hu-berlin.de
https://www2.hu-berlin.de/chemie/arenz/index_engl.htm

University Education

  • 1991-1997 Chemistry Studies (Diploma) at the Universität Bonn
  • 1998-2000 Graduate Studies in bioorganic chemistry, Universität Karlsruhe
  • 2000 Ph.D. (“Dr. rer. nat.”), Universität Karlsruhe
  • 2001-2004 Postdoctoral fellow, Universität Bonn

Professional Experience (selection)

  • 2004-         Junior Professor for Bioorganic Chemistry, HU Berlin
  • 2010-2011 Substitute Professorship for Organic Chemistry, Universität Leipzig

Scientific Scope

  • miRNAs: We try to develop and discover small molecules inhibiting the maturation of specific micro RNAs upregulated in cancer.
  • Sphingolipid Signaling: We develop small molecule inhibitors of enzymes involved in sphingolipid signaling.
  • Hsp70: We elucidate the cancer-specific lysosomal role of Hsp70. We develop molecules that specifically interact with lysosomal Hsp70 and thus should enable lysosome-mediated cell death.

Most important Awards, Grants or Scientific Achievements

  • 2010 Heisenberg Fellowship of the DFG

Selected References

  • Kirkegaard, T., Roth, A.G., Petersen, N.H.T., Mahalka, A.K., Olsen, O.D., Moilanen, I., Zylicz, A., Knudsen, J., Sandhoff, K., Arenz, C., Kinnunen, P.K.J., Nylandsted, J. & Jäättelä, M. (2010). Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology. Nature 463, 549.
  • Roth, A.G, Drescher, D., Yang, Y., Redmer, S., Uhlig, S. & Arenz, C. (2009). Potent and Selective Inhibition of Acid Sphingomyelinase by Bisphosphonates. Angew Chem. Int Ed 48, 7560.
  • Davies, B.P. and Arenz, C. (2006). A Homogenous Assay for Micro RNA Maturation. Angew Chem Int Ed 45, 5048.