• sense clinically
  • think mechanistically
  • act interdisciplinarily
  • treat innovatively

Prof. Dr. rer. nat. Ingeborg Tinhofer-Keilholz

Laboratory for Translational Radiooncology

Dept. of Radiooncology and Radiotherapy
Charité Universitätsmedizin Berlin
Email: ingeborg.tinhofer(at)charite.de


Scientific Scope

The Tinhofer lab mainly focuses on the elucidation of the molecular mechanisms which render head neck squamous cell carcinomas (HNSCC) resistant to radiotherapy, chemotherapy and targeted treatment. By in-depth characterization patients’ tumor tissue specimens and derived preclinical models we are aiming at the elucidation of molecular resistance mechanisms, and the development of biomarkers for improved patient stratification and personalized treatment.

A second focus is to establish liquid biopsy diagnostics for complementary analysis of blood-derived tumor markers, such as circulating tumor cells and plasma-derived cell-free nucleic acids. Here, the long-term goal is the clinical implementation of liquid biopsy assays as a minimally invasive alternative to sequential tumor tissue sampling. This will allow a more individualized selection of treatment and its early adaptation in case of lacking efficacy, and will thereby significantly contribute to improve overall outcome of HNSCC patients.

Please visit the “Labor für Strahlenbiologie” website for more detailed informations (https://radioonkologie.charite.de/forschung/labor_fuer_strahlenbiologie_und_translationale_radioonkologie/).

Group Members

Dr. Ana Pestana (Post-Doc)

Stephanie Staudte (PhD student)

Solenna Bourdier (PhD student)

Stephen George (PhD student)

Mariam Badghdady (PhD student)

Anne-Sophie Fisch (Vet.Med. student)

Vanessa Sachse (Scientific assistant)

Anna Happe-Kramer (Technician)

Julius Handstein (Student assistant)


Selected References