• sense clinically
  • think mechanistically
  • act interdisciplinarily
  • treat innovatively

Prof. Dr. phil. Walter Birchmeier

Signal Transduction in Development and Cancer
Max-Delbrück Center for Molecular Medicine (MDC)
Robert-Rössle-Str. 10
13092 Berlin

E-Mail: wbirch@ mdc-berlin.de

University Education

  • 1966-1970 Studies of Biology and Biochemistry, Diploma, Universität Zürich, Switzerland
  • 1970-1973 Ph.D. Studies at the Institute of Biochemistry, Universität Zürich, Switzerland
  • 1973 Ph.D., Universität Zürich, Switzerland

Professional Experience (selection)

  • 1974-1977 Postdoctoral research fellow at Cornell University, USA, the Biocenter Basel, Switzerland and UCSD, USA
  • 1978-1981 Oberassistent at ETH Zürich, Switzerland
  • 1982-1988 Junior group leader at the Max Planck Institute Tübingen
  • 1988-1993 Full Professor (C4), Universitätsklinik Essen
  • 1993- Group leader (C4) at the MDC
  • 1996- University Professor (C4-S) at the HU Berlin/Charité
  • 2004-2008 Scientific Director of the MDC

Research Fields

  • i) Main field: Role of Wnt/β-catenin and HGF/Met in Development and Cancer
  • ii) Other fields: Metastasis
  • iii) Current research interest: Cancer Stem Cells

Most important Awards, Grants or Scientific Achievements

  • 1990 Award for Cancer Research, Wilhelm-Warner-Stiftung, Hamburg
  • 1992 Meyenburg-Award for Cancer Research, Heidelberg
  • 1999 German Cancer Award (Deutscher Krebspreis), German Cancer Society

Selected References

  • Hellmuth, K., Grosskopf, S., Tung Lum, C., Wuertele, M, …, Kries v., J.P, Rosário, M., Rademann, J., and Birchmeier, W. (2008). Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. Proc Natl Acad Sci USA 105, 7275.
  • Brembeck, F.H., Schwarz-Romond, T., Bakkers, J., Wilhelm, S., Hammerschmidt, M., and Birchmeier, W. (2004). Essential role of BCL9-2 in the switch between beta-catenin’s adhesive and transcriptional functions. Gene Dev 18, 2225.
  • Hülsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., and Birchmeier, W. (2001). Beta-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105, 533.