Projects CRC1588

• A01: Tracing clonal evolution in neuroblastoma by single-cell DNA sequencing
• A02: Dissecting chromatin accessibility and somatic mitochondrial DNA mutational landscapes in single cells during neuroblastoma evolution
• A03: Extrachromosomal DNA (ecDNA) evolution and re-integration as a driver of progression and metastasis
• A04: Spatial organization and function of RNA in primary neuroblastomas and their TME
• A05: The role of epigenetic modifications in neuroblastoma evolution and plasticity,
• A06: The post-translationally modified neuroblastoma proteome as a source for druggable vulnerabilities
• A07: Targeted phosphoproteomics-based prediction of drug responses to combinatorial treatment
• B01: The role of chromosome topology in MYCN function and neuroblastoma evolution and its potential for clinical exploitation
• B02: Targeting MYCN-dependent resolution of transcription-replication conflicts
• B03: Targeting MYCN multiprotein complexes in neuroblastoma with miniproteins
• B04: Targeting rewired ALK/RAS/MAPK signaling in neuroblastoma
• B05: Plasma proteome and metabolome signatures to better understand, monitor and predict neuroblastoma evolution
• B06: Preventing neuroblastoma relapses by molecular characterization and targeted elimination of minimal residual disease cells
• C01: Neuroblastoma cell states and their link to the microenvironment, disease progression and therapy response
• C02: Uncovering neuroblastoma cell plasticity in embryonic grafts using a universal transcription factor network
• C03: Deciphering the principles of neuroblastoma metastasis to the bone marrow by integrated single-cell and spatial multi-omics
• C04: Engineering CAR T cells to better find and eradicate neuroblastoma
• C05: Spontaneous and treatment-induced T cell responses against neuroblastoma
• C06: The role of neuroblastoma-secreted exosomes in pre-metastatic niche formation
• INF: A data analysis ecosystem for the CRC: Omics data processing and management