• sense clinically
  • think mechanistically
  • act interdisciplinarily
  • treat innovatively

PD Dr. rer. nat. Markus Morkel

Laboratory of Molecular Tumor Pathology
BIH Bioportal Single Cells
Institute of Pathology Charité - Universitätsmedizin Berlin 
Charitéplatz 1
10117 Berlin
Tel: +49 30 450 536 107

E-Mail: markus.morkel(at)charite.de




Scientific Scope

My scientific background is in developmental biology and in cancer research, two fields sharing a common interest in signals controlling cell phenotypes and cell developmental trajectories.  In particular, I am interested in the roles of oncogenic signals in controlling cancer cell development. We use transgenic mouse and organoid models and patient-derived tissues and organoids to decipher contributions of individual oncogenes to cancer cell signaling networks, with a focus on Wnt/β-catenin, PI3K-AKT, and MAPK. Furthermore, we employ fluorescent reporters and single cell methodology such as CyTOF and single cell RNA sequencing to assess cell heterogeneity on the levels of the signaling network and the transcriptome, respectively. Generally, our studies are designed to understand how oncogenic signals shape cancer cell phenotypes with the translational aim to identify novel vulnerabilities of cancer signal transduction networks.


Selected References