Prof. Dr. med. Ulrich Keller

Contact Information of Principal Investigator:

AG Ulrich Keller
Med. Klinik Schwerpunkt Hämatologie,
Charité-Universitätsmedizin Berlin
Hindenburgdamm 30
12203 Berlin

E-Mail: ulrich.keller(at)charite.de
Link to homepage: https://haema-cbf.charite.de/forschung/wissenschaftliche_arbeitsgruppen/keller_group/

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Scientific Scope

Mechanism-based cancer therapies

Group Members

Stefanos Bamopoulos, Dr. med., Clinician Scientist

Francis Baumgartner, Dr. med., Clinician Scientist

Marlitt Böger, PhD Student

Uta Demel, Dr. med., Clinician Scientist

Sanket Gosavi, Student

Stefan Habringer, Dr. med. Dr. univ., Clinician Scientist, Team Leader

Gustaaf Heynen, Dr. rer. nat., Scientist

Maximilian Holz, MD Student

Konstandina Isaakidis, M.Sc., Lab Manager

Kaiting Jiang, MD Student

Hazal Köse, PhD Student

Hongyu Liu, Dr. rer. medic., Staff Scientist

Anna Meurer, Clinician Scientist

Maja Milanovic, Dr. rer. nat., Scientist

Markus Schick, Dr. rer. nat., Associated Scientist

Laura Schmalbrock, Dr. med., Clinician Scientist

Veronika Schulze, M.Sc., Technical Assistant

Daniel Steiert, PhD Student

Isabelle Träger, MD Student

Sara Uhan, PhD Student

Philine Wegner, PhD Student

Matthias Wirth, PD Dr. rer. nat., Scientist, Team Leader

Chuanbing Zang, Dr. rer. medic., Staff Scientist

Le Zhang, MD Student

Selected References

Schick M, Zhang L, Maurer S, Maurer HC, Isaakaidis K, Schneider L, Patra U, Schunck K, Rohleder E, Hofstetter J, Baluapuri A, Scherger AK, Slotta-Huspenina J, Hettler F, Weber J, Engleitner T, Maresch R, Slawska J, Lewis R, Istvanffy R, Habringer S, Steiger K, Baiker A, Oostendorp RAJ, Miething C, Lenhof HP, Bassermann F, Chapuy B, Wirth M, Wolf E, Rad R, Müller S, Keller U.: Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma. Nat Commun. 2022
Demel UM, Böger M, Yousefian S, Grunert C, Zhang L, Hotz PW, Gottschlich A, Köse H, Isaakidis K, Vonficht D, Grünschläger F, Rohleder E, Wagner K, Dönig J, Igl V, Brzezicha B, Baumgartner F, Habringer S, Löber J, Chapuy B, Weidinger C, Kobold S, Haas S, Busse AB, Müller S, Wirth M, Schick M, Keller U.: Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer. J Clin Invest. 2022
Doffo J, Bamopoulos SA, Köse H, Orben F, Zang C, Pons M, den Dekker AT, Brouwer RWW, Baluapuri A, Habringer S, Reichert M, Illendula A, Krämer OH, Schick M, Wolf E, van IJcken WFJ, Esposito I, Keller U, Schneider G, Wirth M: NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer. Proc Natl Acad Sci U S A. 2022
Biederstädt, A., Hassan, Z., Schneeweis, C., Schick, M., Schneider, L., Muckenhuber, A., Hong, Y., Siegers, G., Nilsson, L., Wirth, M., Dantes, Z., Steiger, K., Schunck, K., Langston, S., Lenhof, H.P., Coluccio, A., Orben, F., Slawska, J., Scherger, A., Saur, D., Müller, S., Rad, R., Weichert, W., Nilsson, J., Reichert, M., Schneider, G., Keller, U. (2020) "SUMO pathway inhibition targets an aggressive pancreatic cancer subtype." Gut. 2020
O'Connor, T., Zhou, X., Kosla, J., Adili, A., Garcia Beccaria, M., Kotsiliti, E., Pfister, D., Johlke, A.L., Sinha, A., Sankowski, R., Schick, M., Lewis, R., Dokalis, N., Seubert, B., Höchst, B., Inverso, D., Heide, D., Zhang, W., Weihrich, P., Manske, K., Wohlleber, D., Anton, M., Hoellein, A., Seleznik, G., Bremer, J., Bleul, S., Augustin, H.G., Scherer, F., Koedel, U., Weber, A., Protzer, U., Förster, R., Wirth, T., Aguzzi, A., Meissner, F., Prinz, M., Baumann, B., Höpken, U.E., Knolle, P.A., von Baumgarten, L., Keller, U., Heikenwälder, M. (2019) "Age-related Gliosis Promotes Central Nervous System Lymphoma through CCL19-mediated Tumor Cell Retention." Cancer Cell. 2019