Prof. Dr. rer. nat. Andreas Herrmann

Scientific Scope

The Molecular Biophysics group at Humboldt-Universität zu Berlin is studying the molecular mechanisms of the infection cycle of enveloped viruses. Influenza and Hantaviruses are in the focus of our research. We are investigating virus entry, intracellular trafficking of viruses and components, membrane fusion, dynamics of the viral genome, its bundling and packaging, and the assembly and budding new virions. We have developed and patented highly efficient biomimetic multivalent inhibitors of virus binding to host cells. To understand the complex formation of the highly segmented genome of influenza viruses, we have identified pathways of segment association by setting up a new multicolor and multitargeting FISH approach enabling the identification of 16 different viral RNA components at single cell level.

Group Members

www2.hu-berlin.de/biologie/molbp/

Most important Awards, Grants or Scientific Achievements

• 2001 Prix Gay/Lussac of the French Ministry of Research, France

Selected References

• Haralampiev, I., Prisner, S., Nitzan, M., Schade, M., Jolmes, F., Schreiber, M., Loidolt-Krüger, M., Jongen, K., Chamiolo, J., Nilson, N., Winter, F., Friedman, N., Seitz, O., Wolff, T., & Herrmann, A. (2020). Selective flexible packaging pathways of the segmented genome of influenza A virus. Nature communications, 11(1), 4355.
• Cuellar-Camacho, J. L., Bhatia, S., Reiter-Scherer, V., Lauster, D., Liese, S., Rabe, J. P., Herrmann, A., & Haag, R. (2020). Quantification of Multivalent Interactions between Sialic Acid and Influenza A Virus Spike Proteins by Single-Molecule Force Spectroscopy. Journal of the American Chemical Society, 142(28), 12181–12192.
• Müller, M., Lauster, D., Wildenauer, H., Herrmann, A., & Block, S. (2019). Mobility-Based Quantification of Multivalent Virus-Receptor Interactions: New Insights Into Influenza A Virus Binding Mode. Nano letters, 19(3), 1875–1882.
• Donskyi, I., Drüke, M., Silberreis, K., Lauster, D., Ludwig, K., Kühne, C., Unger, W., Böttcher, C., Herrmann, A., Dernedde, J., Adeli, M., & Haag, R. (2018). Interactions of Fullerene-Polyglycerol Sulfates at Viral and Cellular Interfaces. Small (Weinheim an der Bergstrasse, Germany), 14(17), e1800189.
• Bandlow, V., Liese, S., Lauster, D., Ludwig, K., Netz, R. R., Herrmann, A., & Seitz, O. (2017). Spatial Screening of Hemagglutinin on Influenza A Virus Particles: Sialyl-LacNAc Displays on DNA and PEG Scaffolds Reveal the Requirements for Bivalency Enhanced Interactions with Weak Monovalent Binders. Journal of the American Chemical Society, 139(45), 16389–16397.
• Lauster, D., Glanz, M., Bardua, M., Ludwig, K., Hellmund, M., Hoffmann, U., Hamann, A., Böttcher, C., Haag, R., Hackenberger, C., & Herrmann, A. (2017). Multivalent Peptide-Nanoparticle Conjugates for Influenza-Virus Inhibition. Angewandte Chemie (International ed. in English), 56(21), 5931–5936.
• Sieben, C., & Herrmann, A. (2017). Single virus force spectroscopy: The ties that bind. Nature nanotechnology, 12(2), 102–103.
• Pinkert, T., Furkert, D., Korte, T., Herrmann, A., & Arenz, C. (2017). Amplification of a FRET Probe by Lipid-Water Partition for the Detection of Acid Sphingomyelinase in Live Cells. Angewandte Chemie (International ed. in English), 56(10), 2790–2794.
• Haralampiev, I., Mertens, M., Schwarzer, R., Herrmann, A., Volkmer, R., Wessig, P., & Müller, P. (2015). Recruitment of SH-containing peptides to lipid and biological membranes through the use of a palmitic acid functionalized with a maleimide group. Angewandte Chemie (International ed. in English), 54(1), 323–326.
• Beutel, O., Nikolaus, J., Birkholz, O., You, C., Schmidt, T., Herrmann, A., & Piehler, J. (2014). High-fidelity protein targeting into membrane lipid microdomains in living cells. Angewandte Chemie (International ed. in English), 53(5), 1311–1315.
• Scheidt, H. A., Meyer, T., Nikolaus, J., Baek, D. J., Haralampiev, I., Thomas, L., Bittman, R., Müller, P., Herrmann, A., & Huster, D. (2013). Cholesterol's aliphatic side chain modulates membrane properties. Angewandte Chemie (International ed. in English), 52(49), 12848–12851.
• Schade, M., Knoll, A., Vogel, A., Seitz, O., Liebscher, J., Huster, D., Herrmann, A., & Arbuzova, A. (2012). Remote control of lipophilic nucleic acids domain partitioning by DNA hybridization and enzymatic cleavage. Journal of the American Chemical Society, 134(50), 20490–20497.
• Sieben, C., Kappel, C., Zhu, R., Wozniak, A., Rankl, C., Hinterdorfer, P., Grubmüller, H., & Herrmann, A. (2012). Influenza virus binds its host cell using multiple dynamic interactions. Proceedings of the National Academy of Sciences of the United States of America, 109(34), 13626–13631.
• Weise, K., Kapoor, S., Denter, C., Nikolaus, J., Opitz, N., Koch, S., Triola, G., Herrmann, A., Waldmann, H., & Winter, R. (2011). Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms. Journal of the American Chemical Society, 133(4), 880–887.
• Kummer, S., Knoll, A., Socher, E., Bethge, L., Herrmann, A., & Seitz, O. (2011). Fluorescence imaging of influenza H1N1 mRNA in living infected cells using single-chromophore FIT-PNA. Angewandte Chemie (International ed. in English), 50(8), 1931–1934.
• Loew, M., Springer, R., Scolari, S., Altenbrunn, F., Seitz, O., Liebscher, J., Huster, D., Herrmann, A., & Arbuzova, A. (2010). Lipid domain specific recruitment of lipophilic nucleic acids: a key for switchable functionalization of membranes. Journal of the American Chemical Society, 132(45), 16066–16072.