The Molecular Biophysics group at Humboldt-Universität zu Berlin is studying the molecular mechanisms of the infection cycle of enveloped viruses. Influenza and Hantaviruses are in the focus of our research. We are investigating virus entry, intracellular trafficking of viruses and components, membrane fusion, dynamics of the viral genome, its bundling and packaging, and the assembly and budding new virions. We have developed and patented highly efficient biomimetic multivalent inhibitors of virus binding to host cells. To understand the complex formation of the highly segmented genome of influenza viruses, we have identified pathways of segment association by setting up a new multicolor and multitargeting FISH approach enabling the identification of 16 different viral RNA components at single cell level.
- 2001 Prix Gay/Lussac of the French Ministry of Research, France
- Sieben, C., Kappel, C., Zhu, R., Wozniak, A., Rankl, C., Hinterdorfer, P., Grubmüller, H., Herrmann, A. (2012) Influenza virus binds its host cell using multiple dynamic interactions. Proc Natl Acad Sci U S A. 109:13626-13631
- Schwarzer, R., Levental, I., Gramatica, A., Scolari, S., Buschmann, V., Veit, M., Herrmann, A. (2014) The cholesterol-binding motif of the HIV-1 glycoprotein gp41 regulates lateral sorting and oligomerization. Cell. Microbiol. 16, 1565-1581.
- Lauster, D., Glanz, M., Bardua, M., Ludwig, K., Hellmund, M., Hoffmann, U., Hamann, A., Böttcher, C., Haag, R., Hackenberger, C., Herrmann, A. (2017) Multivalent Peptide-Nanoparticle-conjugates for Influenza Virus Inhibition. Internat. Ed. Angewandte Chemie, 56, 5931-5936
- Bandlow, V., Liese, S., Lauster, D., Ludwig, K., Netz, R., Herrmann, A., Seitz, O. (2017) Spatial screening of hemagglutinin on Influenza A virus particles: Sialyl-LacNAc displays on DNA and PEG scaffolds reveal the requirements for bivalency enhanced interactions with weak monovalent binders. JACS, 139(45):16389-1637.