Prof. Dr. rer. nat. Claus Scheidereit

University Education

• 1982 Diploma in Chemistry, Universität Marburg
• 1984 Dr. rer. nat., Universität Marburg (with honours)

Professional Experience (selection)

• 1984-1985 Postdoctoral fellow, Universität Marburg
• 1986-1988 Postdoctoral fellow, Rockefeller University, USA
• 1989-1994 Independent research group leader, MPI for Melecular Genetics, Berlin
• 1994- Research group leader, MDC
• Coordinator of the MDC Cancer Research Program

Research

Our laboratory is interested in signal transduction processes that activate the inducible transcription factor nuclear factor-κB (NF-κB) as well as in regulatory mechanisms that control the activity of NF-κB in the nucleus.

NF-κB and its regulators provide an excellent model system with broad physiological and medical significance. The transcription factor controls important steps in immunity and inflammation, as well as cell death, proliferation or metabolism. Its activity is controlled by inhibitory IκB proteins and the IκB kinase (IKK) complex.

We wish to decipher mechanisms that underlie gene regulation by IKK and NF-κB in development and diseases. To reach these goals, we are utilizing a wide variety of approaches, including classical biochemistry, mouse-models, 3D optical imaging, systems biology, genome-wide target gene determination and siRNA screening as well as mass spectrometry (MS)-based proteomics.

Most important Awards, Grants or Scientific Achievements

• 2005 German Cancer Prize, Deutsche Krebsgesellschaft e.V.
• Member of the Advisory Editorial Board, EMBO Reports

Selected References

• von Hoff, L., Kärgel, E., Franke, V., McShane, E., Schulz-Beiss, K. W., Patone, G., Schleussner, N., Kolesnichenko, M., Hübner, N., Daumke, O., Selbach, M., Akalin, A., Mathas, S., & Scheidereit, C. (2019). Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma. Blood, 133(13), 1489–1494.
• Murakawa, Y., Hinz, M., Mothes, J., Schuetz, A., Uhl, M., Wyler, E., Yasuda, T., Mastrobuoni, G., Friedel, C. C., Dölken, L., Kempa, S., Schmidt-Supprian, M., Blüthgen, N., Backofen, R., Heinemann, U., Wolf, J., Scheidereit, C., & Landthaler, M. (2015). RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway. Nature communications, 6, 7367.
• Kreher, S., Bouhlel, M. A., Cauchy, P., Lamprecht, B., Li, S., Grau, M., Hummel, F., Köchert, K., Anagnostopoulos, I., Jöhrens, K., Hummel, M., Hiscott, J., Wenzel, S. S., Lenz, P., Schneider, M., Küppers, R., Scheidereit, C., Giefing, M., Siebert, R., Rajewsky, K., … Mathas, S. (2014). Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma. Proceedings of the National Academy of Sciences of the United States of America, 111(42), E4513–E4522.
• Nogai, H., Wenzel, S. S., Hailfinger, S., Grau, M., Kaergel, E., Seitz, V., Wollert-Wulf, B., Pfeifer, M., Wolf, A., Frick, M., Dietze, K., Madle, H., Tzankov, A., Hummel, M., Dörken, B., Scheidereit, C., Janz, M., Lenz, P., Thome, M., & Lenz, G. (2013). IκB-ζ controls the constitutive NF-κB target gene network and survival of ABC DLBCL. Blood, 122(13), 2242–2250.
• Lehmann, S. M., Krüger, C., Park, B., Derkow, K., Rosenberger, K., Baumgart, J., Trimbuch, T., Eom, G., Hinz, M., Kaul, D., Habbel, P., Kälin, R., Franzoni, E., Rybak, A., Nguyen, D., Veh, R., Ninnemann, O., Peters, O., Nitsch, R., Heppner, F. L., … Lehnardt, S. (2012). An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nature neuroscience, 15(6), 827–835.
• Voutilainen, M., Lindfors, P. H., Lefebvre, S., Ahtiainen, L., Fliniaux, I., Rysti, E., Murtoniemi, M., Schneider, P., Schmidt-Ullrich, R., & Mikkola, M. L. (2012). Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-κB. Proceedings of the National Academy of Sciences of the United States of America, 109(15), 5744–5749.
• Jing, H., Kase, J., Dörr, J. R., Milanovic, M., Lenze, D., Grau, M., Beuster, G., Ji, S., Reimann, M., Lenz, P., Hummel, M., Dörken, B., Lenz, G., Scheidereit, C., Schmitt, C. A., & Lee, S. (2011). Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations. Genes & development, 25(20), 2137–2146.
• Hinz, M., Stilmann, M., Arslan, S. Ç., Khanna, K. K., Dittmar, G., & Scheidereit, C. (2010). A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. Molecular cell, 40(1), 63–74.
• Rauch, A., Seitz, S., Baschant, U., Schilling, A. F., Illing, A., Stride, B., Kirilov, M., Mandic, V., Takacz, A., Schmidt-Ullrich, R., Ostermay, S., Schinke, T., Spanbroek, R., Zaiss, M. M., Angel, P. E., Lerner, U. H., David, J. P., Reichardt, H. M., Amling, M., Schütz, G., … Tuckermann, J. P. (2010). Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell metabolism, 11(6), 517–531.
• Stilmann, M., Hinz, M., Arslan, S. C., Zimmer, A., Schreiber, V., & Scheidereit, C. (2009). A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation. Molecular cell, 36(3), 365–378.
• Henke, N., Schmidt-Ullrich, R., Dechend, R., Park, J. K., Qadri, F., Wellner, M., Obst, M., Gross, V., Dietz, R., Luft, F. C., Scheidereit, C., & Muller, D. N. (2007). Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage. Circulation research, 101(3), 268–276.
• Wegener, E., Oeckinghaus, A., Papadopoulou, N., Lavitas, L., Schmidt-Supprian, M., Ferch, U., Mak, T. W., Ruland, J., Heissmeyer, V., & Krappmann, D. (2006). Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. Molecular cell, 23(1), 13–23.
• Visekruna, A., Joeris, T., Seidel, D., Kroesen, A., Loddenkemper, C., Zeitz, M., Kaufmann, S. H., Schmidt-Ullrich, R., & Steinhoff, U. (2006). Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis. The Journal of clinical investigation, 116(12), 3195–3203.
• Unterstab, G., Ludwig, S., Anton, A., Planz, O., Dauber, B., Krappmann, D., Heins, G., Ehrhardt, C., & Wolff, T. (2005). Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1. Proceedings of the National Academy of Sciences of the United States of America, 102(38), 13640–13645.
• Choi, M., Rolle, S., Wellner, M., Cardoso, M. C., Scheidereit, C., Luft, F. C., & Kettritz, R. (2003). Inhibition of NF-kappaB by a TAT-NEMO-binding domain peptide accelerates constitutive apoptosis and abrogates LPS-delayed neutrophil apoptosis. Blood, 102(6), 2259–2267.
• Mathas, S., Lietz, A., Janz, M., Hinz, M., Jundt, F., Scheidereit, C., Bommert, K., & Dorken, B. (2003). Inhibition of NF-kappaB essentially contributes to arsenic-induced apoptosis. Blood, 102(3), 1028–1034.
• Scheidereit, C., Cromlish, J. A., Gerster, T., Kawakami, K., Balmaceda, C. G., Currie, R. A., & Roeder, R. G. (1988). A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein. Nature, 336(6199), 551–557.
• Hinz, M., Krappmann, D., Eichten, A., Heder, A., Scheidereit, C., & Strauss, M. (1999). NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Molecular and cellular biology, 19(4), 2690–2698.
• Bargou, R. C., Emmerich, F., Krappmann, D., Bommert, K., Mapara, M. Y., Arnold, W., Royer, H. D., Grinstein, E., Greiner, A., Scheidereit, C., & Dörken, B. (1997). Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. The Journal of clinical investigation, 100(12), 2961–2969.
• Scheidereit C. (2006). IkappaB kinase complexes: gateways to NF-kappaB activation and transcription. Oncogene, 25(51), 6685–6705.
• Scheidereit, C., Geisse, S., Westphal, H. M., & Beato, M. (1983). The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus. Nature, 304(5928), 749–752.