• sense clinically
  • think mechanistically
  • act interdisciplinarily
  • treat innovatively

Prof. Dr. rer. nat. Michael Hummel

Molecular Diagnostics
Institute of Pathology
Charité - Universitätsmedizin Berlin
Charitéplatz 1
10117 Berlin
Tel: +49 30 450 536 642
E-Mail: michael.hummel@ charite.de

University Education

  • 1985 Diploma, Institute of Biology, University Cologne

Professional Experience (selection)

  • 1986-1990 Ph.D. student, Institute of Pathology, FU Berlin
  • 1990-1999 Postdoctoral research fellow, Institute of Pathology, FU Berlin
  • 1994- Head of the Molecular Pathology Group, Institute of Pathology, Charité

Research Fields

  • Main field: Molecular mechanisms in malignant lymphomas
  • Current research interest: Epigenetic gene regulation in Hodgkin lymphoma
  • Identification of biomarkers for precision oncology

Most important Awards, Grants or Scientific Achievements

  • 1986-1988 Berlin Senate (NAFöG)
  • 2008- Member, Deutsche Krebsgesellschaft, Abteilung Experimentelle Krebsforschung (AEK) e.V.
  • Director of the German Biobank Node/Alliance
  • Head of the Central Biobank Charité (ZeBanC)

Selected References

  • Ritter J, Seitz V, Balzer H, Gary R, Lenze D, Moi S, Pasemann S, Seegebarth A, Wurdack M, Hennig S, Gerbitz A & Hummel M. Donor CD4 T cell diversity determines virus reactivation in patients after HLA-matched allogeneic stem cell transplantation. American Journal of Transplantation. 2015; 15(8): 2170-2179
  • Dimitrova L, Seitz V, Hecht J, Lenze D, Hansen P, Szczepanowski M, Ma L, Oker E, Sommerfeld A, Jundt F, Klapper W, Hummel M. PAX5 overexpression is not enough to re-establish the mature B-cell phenotype in classical Hodgkin lymphoma. Leukemia. 2014 Jan; 28(1): 213-6
  • V Laffert M, Warth A, Penzel R, Schirmacher P, Jonigk D, Kreipe H, Schildhaus HU, Merkelbach-Bruse HS, Büttner R, Reu S, Kerler R, Jung A, Kirchner T, Wölfel C, Petersen I, Rodriguez R, Jochum W, Bartsch H, Fisseler-Eckhoff A, Berg E, Lenze D, Dietel M, Hummel M. Anaplastic lymphoma kinase (ALK) gene rearrangement in non-small cell lung cancer (NSCLC): results of a multi-center ALK-testing. Lung Cancer. 2013 Aug; 81(2): 200-6
  • Joosten M, Seitz V, Zimmermann K, Sommerfeld A, Berg E, Lenze D, Leser U, Stein H, Hummel M. Histone acetylation and DNA de-methylation of T cells result in an anaplastic large cell lymphoma-like phenotype. Haematologica. 2013. Feb; 98(2): 247-54
  • Seitz V, Thomas PE, Zimmermann K, Paul U, Ehlers A, Joosten M, Dimtrova L, Lenze D, Sommerfeld A, Oker E, Leser U, Stein H, Hummel M. Classical Hodgkin's Lymphoma shows epigenetic features of abortive plasma cell differentiation. Haematologica. 2011; Jun 96(6): 863-70
  • Seitz V, Butzhammer P, Hirsch B, Hecht J, Gütgemann I, Ehlers A, Lenze D, Oker E, Sommerfeld A, von der Wall E, König C, Zinser C, Spang R, Hummel M. Deep sequencing of MYC DNA-binding sites in Burkitt Lymphoma. PLoS One. 2011; 6(11)
  • Ehlers, A., Oker, E., Bentink, S., Lenze, D., Stein, H., and Hummel, M. Histone acetylation and DNA demethylation of B-cells result in a Hodgkin-like phenotype. Leukemia. 2008; 22(4): 835-41
  • Hummel, M., Bentink, S., Berger, H., Klapper, W., Wessendorf, S.,…, Siebert, R. A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. New Engl J of Med. 2006; 354(23): 2419-2430
  • Marafioti T, Hummel M, Anagnostopoulos I, Foss HD, Falini B, Delsol G, Isaacson PG, Pileri S and Stein H. Origin of nodular lymphocate-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells. New New Engl J of Med. 1997; 333(14): 901-906
  • Hummel M, Ziemann K, Lammert S, Pileri E, Sabattini E and Stein H. Hodgkin's disease with mono-clonal and polyclonal populations of Reed-Sternberg cells. New Engl J of Med. 1995; 333(14): 901-906