Prof. Dr. rer. nat. Michael Hummel

University Education

• 1985 Diploma, Institute of Biology, University Cologne

Professional Experience (selection)

• 1986-1990 Ph.D. student, Institute of Pathology, FU Berlin
• 1990-1999 Postdoctoral research fellow, Institute of Pathology, FU Berlin
• 1994- Head of the Molecular Pathology Group, Institute of Pathology, Charité

Research Fields

• Main field: Molecular mechanisms in malignant lymphomas
• Current research interest: Epigenetic gene regulation in Hodgkin lymphoma
• Identification of biomarkers for precision oncology

Most important Awards, Grants or Scientific Achievements

• 1986-1988 Berlin Senate (NAFöG)
• 2008- Member, Deutsche Krebsgesellschaft, Abteilung Experimentelle Krebsforschung (AEK) e.V.
• Director of the German Biobank Node/Alliance
• Head of the Central Biobank Charité (ZeBanC)

Selected References

• Schulte-Schrepping, J., Reusch, N., Paclik, D., Baßler, K., Schlickeiser, S., Zhang, B., Krämer, B., Krammer, T., Brumhard, S., Bonaguro, L., De Domenico, E., Wendisch, D., Grasshoff, M., Kapellos, T. S., Beckstette, M., Pecht, T., Saglam, A., Dietrich, O., Mei, H. E., Schulz, A. R., … Deutsche COVID-19 OMICS Initiative (DeCOI) (2020). Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell, 182(6), 1419–1440.e23.
• López, C., Kleinheinz, K., Aukema, S. M., Rohde, M., Bernhart, S. H., Hübschmann, D., Wagener, R., Toprak, U. H., Raimondi, F., Kreuz, M., Waszak, S. M., Huang, Z., Sieverling, L., Paramasivam, N., Seufert, J., Sungalee, S., Russell, R. B., Bausinger, J., Kretzmer, H., Ammerpohl, O., … Siebert, R. (2019). Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma. Nature communications, 10(1), 1459.
• Loibl, S., Treue, D., Budczies, J., Weber, K., Stenzinger, A., Schmitt, W. D., Weichert, W., Jank, P., Furlanetto, J., Klauschen, F., Karn, T., Pfarr, N., von Minckwitz, G., Möbs, M., Jackisch, C., Sers, C., Schneeweiss, A., Fasching, P. A., Schem, C., Hummel, M., … Denkert, C. (2019). Mutational Diversity and Therapy Response in Breast Cancer: A Sequencing Analysis in the Neoadjuvant GeparSepto Trial. Clinical cancer research : an official journal of the American Association for Cancer Research, 25(13), 3986–3995.
• Wittenbrink, N., Ananthasubramaniam, B., Münch, M., Koller, B., Maier, B., Weschke, C., Bes, F., de Zeeuw, J., Nowozin, C., Wahnschaffe, A., Wisniewski, S., Zaleska, M., Bartok, O., Ashwal-Fluss, R., Lammert, H., Herzel, H., Hummel, M., Kadener, S., Kunz, D., & Kramer, A. (2018). High-accuracy determination of internal circadian time from a single blood sample. The Journal of clinical investigation, 128(9), 3826–3839.
• Milanovic, M., Fan, D., Belenki, D., Däbritz, J., Zhao, Z., Yu, Y., Dörr, J. R., Dimitrova, L., Lenze, D., Monteiro Barbosa, I. A., Mendoza-Parra, M. A., Kanashova, T., Metzner, M., Pardon, K., Reimann, M., Trumpp, A., Dörken, B., Zuber, J., Gronemeyer, H., Hummel, M., … Schmitt, C. A. (2018). Senescence-associated reprogramming promotes cancer stemness. Nature, 553(7686), 96–100.
• Ritter, J., Zimmermann, K., Jöhrens, K., Mende, S., Seegebarth, A., Siegmund, B., Hennig, S., Todorova, K., Rosenwald, A., Daum, S., Hummel, M., & Schumann, M. (2018). T-cell repertoires in refractory coeliac disease. Gut, 67(4), 644–653.
• Gröbner, S. N., Worst, B. C., Weischenfeldt, J., Buchhalter, I., Kleinheinz, K., Rudneva, V. A., Johann, P. D., Balasubramanian, G. P., Segura-Wang, M., Brabetz, S., Bender, S., Hutter, B., Sturm, D., Pfaff, E., Hübschmann, D., Zipprich, G., Heinold, M., Eils, J., Lawerenz, C., Erkek, S., … Pfister, S. M. (2018). The landscape of genomic alterations across childhood cancers. Nature, 555(7696), 321–327.
• Staiger, A. M., Ziepert, M., Horn, H., Scott, D. W., Barth, T., Bernd, H. W., Feller, A. C., Klapper, W., Szczepanowski, M., Hummel, M., Stein, H., Lenze, D., Hansmann, M. L., Hartmann, S., Möller, P., Cogliatti, S., Lenz, G., Trümper, L., Löffler, M., Schmitz, N., … German High-Grade Lymphoma Study Group (2017). Clinical Impact of the Cell-of-Origin Classification and the MYC/ BCL2 Dual Expresser Status in Diffuse Large B-Cell Lymphoma Treated Within Prospective Clinical Trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 35(22), 2515–2526.
• Du, J., Neuenschwander, M., Yu, Y., Däbritz, J. H., Neuendorff, N. R., Schleich, K., Bittner, A., Milanovic, M., Beuster, G., Radetzki, S., Specker, E., Reimann, M., Rosenbauer, F., Mathas, S., Lohneis, P., Hummel, M., Dörken, B., von Kries, J. P., Lee, S., & Schmitt, C. A. (2017). Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma. Blood, 129(1), 71–81.
• Mansouri, L., Noerenberg, D., Young, E., Mylonas, E., Abdulla, M., Frick, M., Asmar, F., Ljungström, V., Schneider, M., Yoshida, K., Skaftason, A., Pandzic, T., Gonzalez, B., Tasidou, A., Waldhueter, N., Rivas-Delgado, A., Angelopoulou, M., Ziepert, M., Arends, C. M., Couronné, L., … Damm, F. (2016). Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma. Blood, 128(23), 2666–2670.
• Leich, E., Hoster, E., Wartenberg, M., Unterhalt, M., Siebert, R., Koch, K., Klapper, W., Engelhard, M., Puppe, B., Horn, H., Staiger, A. M., Stuhlmann-Laeisz, C., Bernd, H. W., Feller, A. C., Hummel, M., Lenze, D., Stein, H., Hartmann, S., Hansmann, M. L., Möller, P., … German Low Grade Lymphoma Study Group (GLSG) (2016). Similar clinical features in follicular lymphomas with and without breaks in the BCL2 locus. Leukemia, 30(4), 854–860.
• Seitz, V., Schaper, S., Dröge, A., Lenze, D., Hummel, M., & Hennig, S. (2015). A new method to prevent carry-over contaminations in two-step PCR NGS library preparations. Nucleic acids research, 43(20), e135.
• Kretzmer, H., Bernhart, S. H., Wang, W., Haake, A., Weniger, M. A., Bergmann, A. K., Betts, M. J., Carrillo-de-Santa-Pau, E., Doose, G., Gutwein, J., Richter, J., Hovestadt, V., Huang, B., Rico, D., Jühling, F., Kolarova, J., Lu, Q., Otto, C., Wagener, R., Arnolds, J., … Radlwimmer, B. (2015). DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control. Nature genetics, 47(11), 1316–1325.
• Rahal, R., Frick, M., Romero, R., Korn, J. M., Kridel, R., Chan, F. C., Meissner, B., Bhang, H. E., Ruddy, D., Kauffmann, A., Farsidjani, A., Derti, A., Rakiec, D., Naylor, T., Pfister, E., Kovats, S., Kim, S., Dietze, K., Dörken, B., Steidl, C., … Stegmeier, F. (2014). Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma. Nature medicine, 20(1), 87–92.
• Jäger, N., Schlesner, M., Jones, D. T., Raffel, S., Mallm, J. P., Junge, K. M., Weichenhan, D., Bauer, T., Ishaque, N., Kool, M., Northcott, P. A., Korshunov, A., Drews, R. M., Koster, J., Versteeg, R., Richter, J., Hummel, M., Mack, S. C., Taylor, M. D., Witt, H., … Eils, R. (2013). Hypermutation of the inactive X chromosome is a frequent event in cancer. Cell, 155(3), 567–581. 
• Dörr, J. R., Yu, Y., Milanovic, M., Beuster, G., Zasada, C., Däbritz, J. H., Lisec, J., Lenze, D., Gerhardt, A., Schleicher, K., Kratzat, S., Purfürst, B., Walenta, S., Mueller-Klieser, W., Gräler, M., Hummel, M., Keller, U., Buck, A. K., Dörken, B., Willmitzer, L., … Schmitt, C. A. (2013). Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. Nature, 501(7467), 421–425.
• Richter, J., Schlesner, M., Hoffmann, S., Kreuz, M., Leich, E., Burkhardt, B., Rosolowski, M., Ammerpohl, O., Wagener, R., Bernhart, S. H., Lenze, D., Szczepanowski, M., Paulsen, M., Lipinski, S., Russell, R. B., Adam-Klages, S., Apic, G., Claviez, A., Hasenclever, D., Hovestadt, V., … ICGC MMML-Seq Project (2012). Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nature genetics, 44(12), 1316–1320.
• Lamprecht, B., Walter, K., Kreher, S., Kumar, R., Hummel, M., Lenze, D., Köchert, K., Bouhlel, M. A., Richter, J., Soler, E., Stadhouders, R., Jöhrens, K., Wurster, K. D., Callen, D. F., Harte, M. F., Giefing, M., Barlow, R., Stein, H., Anagnostopoulos, I., Janz, M., … Mathas, S. (2010). Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma. Nature medicine, 16(5), 571–579.
• Hummel, M., Bentink, S., Berger, H., Klapper, W., Wessendorf, S., Barth, T. F., Bernd, H. W., Cogliatti, S. B., Dierlamm, J., Feller, A. C., Hansmann, M. L., Haralambieva, E., Harder, L., Hasenclever, D., Kühn, M., Lenze, D., Lichter, P., Martin-Subero, J. I., Möller, P., Müller-Hermelink, H. K., … Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe (2006). A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. The New England journal of medicine, 354(23), 2419–2430.
• Mathas, S., Janz, M., Hummel, F., Hummel, M., Wollert-Wulf, B., Lusatis, S., Anagnostopoulos, I., Lietz, A., Sigvardsson, M., Jundt, F., Jöhrens, K., Bommert, K., Stein, H., & Dörken, B. (2006). Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma. Nature immunology, 7(2), 207–215.
• Assaf, C., Coupland, S. E., Hummel, M., Jahnke, K., Mostafafivar, S., Stein, H., Orfanos, C. E., & Zouboulis, C. (2005). Relapse of primary extranodal marginal-zone B-cell lymphoma of the dura mater. The Lancet. Oncology, 6(3), 187–189.
• van Dongen, J. J., Langerak, A. W., Brüggemann, M., Evans, P. A., Hummel, M., Lavender, F. L., Delabesse, E., Davi, F., Schuuring, E., García-Sanz, R., van Krieken, J. H., Droese, J., González, D., Bastard, C., White, H. E., Spaargaren, M., González, M., Parreira, A., Smith, J. L., Morgan, G. J., … Macintyre, E. A. (2003). Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia, 17(12), 2257–2317.