• sense clinically
  • think mechanistically
  • act interdisciplinarily
  • treat innovatively

Prof. Dr. rer. nat. Nils Blüthgen

Computational Modelling in Medicine
Charité - Universitätsmedizin Berlin
Institut für Pathologie
Charitplatz 1
10117 Berlin

E-Mail: nils.bluethgen@ charite.de
https://www.sys-bio.net/

University Education

  • 1996-2002 Undergraduate studies in Physics, University of Heidelberg and TU Berlin
  • 2002-2005 PhD in Biophysics, Humboldt University Berlin

Professional Experience (selection)

  • 2005-2006 Postdoc in Molecular Neuroscience with Prof. Dietmar Kuhl, FU Berlin
  • 2007-2008 Research Fellow at Manchester Interdisciplinary Biocentre, University of Manchester
  • 2008- Group leader at Institutes of Pathology and Theoretical Biology, Charite

Most important Awards, Grants or Scientific Achievements

  • 2011 EMBO Fellowship
  • 2008 MTZ award for medical systems biology
  • 2007 FEBS Gosau systems biology award

Selected References

  • Stelniec, I, Legewie, S, Tchernitsa, O, Witzel, F, Klinger, B, Sers, C, Herzel, H, Blüthgen, N* and Schäfer, R* (2012).
Reverse-engineering a hierarchical regulatory network downstream of oncogenic KRAS.
Molecular Systems Biology, 8, 601.
  • Nora, EP, Lajoie, BR, Schulz, EG, Giorgetti, L, Okamoto, I, Servant, N, Piolot, T, Berkum, NL v., Meisig, J, Sedat, J, Gribnau, J, Barillot, E, Blüthgen, N, Dekker, J and Heard, E (2012).
Spatial partitioning of the regulatory landscape of the X-inactivation centre.
Nature, 485, 381-385.
  • Fritsche-Guenther, R., Witzel, F., Sieber, A., Herr, R., Schmidt, N., Braun, S., Brummer, T., Sers, C. and Blüthgen, N (2011).
Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.
Molecular Systems Biology, 7, 489.
  • Jürchot, K., Kunban, R., Krecht, T., Blüthgen, N., Stein, U., Walther, W., Friese, C., Kielbasa, S. M, Ungethüm, U., Lund, P., Knösel, T., Kemmner, W., Morkel, M., Fritzmann, J., Schlag, P. M., Birchmeier, W., Krueger, T., Sperling, S., Sers, C., Royer, H., Herzel, H. and Schäfer, R (2010).
Identification of Y-Box Binding Protein 1 As a Core Regulator of MEK/ERK Pathway-Dependent Gene Signatures in Colorectal Cancer Cells.
PLoS Genetics, 6, e1001231.
  • Kielbasa, SM, Klein, H., Roider, H., Vingron, M. and Blüthgen, N (2010).
TransFind - Predicting transcriptional regulators for gene sets.
Nucleic Acids Research, 38, W275-W280.
  • Parikh, J, Klinger, B, Xia, Y, Marto, JA and Blüthgen, N (2010).
Discovering causal signaling pathways through gene expression patterns.
Nucleic Acids Research, 38, W109-W117.
  • Blüthgen, N., Legewie, S., Kielbasa, S. M, Schramme, A., Tchernitsa, O., Keil, J., Solf, A., Vingron, M., Schäfer, R., Herzel, H. and Sers, C (2009).
A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts.
FEBS Journal, 276, 1024-35.
  • Legewie, S., Herzel, H., Westerhoff, H. V and Blüthgen, N (2008).
Recurrent design patterns in the feedback regulation of the mammalian signalling network.
Molecular Systems Biology, 4, 190.
  • Blüthgen, N. and Legewie, S (2008).
Systems analysis of MAPK signal transduction.
Essays in Biochemistry, 45, 95-107.
  • Blüthgen, N., Menzel, F., Hovestadt, T., Fiala, B. and Blüthgen, N (2007).
Specialization, constraints, and conflicting interests in mutualistic networks.
Current Biology, 17: 341-6, 2007