Prof. Dr. rer. nat. Nils Blüthgen

University Education

• 1996-2002 Undergraduate studies in Physics, University of Heidelberg and TU Berlin
• 2002-2005 PhD in Biophysics, Humboldt University Berlin

Professional Experience (selection)

• 2005-2006 Postdoc in Molecular Neuroscience with Prof. Dietmar Kuhl, FU Berlin
• 2007-2008 Research Fellow at Manchester Interdisciplinary Biocentre, University of Manchester
• 2008- Group leader at Institutes of Pathology and Theoretical Biology, Charite

Most important Awards, Grants or Scientific Achievements

• 2011 EMBO Fellowship
• 2008 MTZ award for medical systems biology
• 2007 FEBS Gosau systems biology award

Selected References

• Meisig, J., Dreser, N., Kapitza, M., Henry, M., Rotshteyn, T., Rahnenführer, J., Hengstler, J. G., Sachinidis, A., Waldmann, T., Leist, M., & Blüthgen, N. (2020). Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation. Nucleic acids research, 48(22), 12577–12592.
• Rydenfelt, M., Klinger, B., Klünemann, M., & Blüthgen, N. (2020). SPEED2: inferring upstream pathway activity from differential gene expression. Nucleic acids research, 48(W1), W307–W312.
• Saez-Rodriguez, J., & Blüthgen, N. (2020). Personalized signaling models for personalized treatments. Molecular systems biology, 16(1), e9042.
• Brandt, R., Sell, T., Lüthen, M., Uhlitz, F., Klinger, B., Riemer, P., Giesecke-Thiel, C., Schulze, S., El-Shimy, I. A., Kunkel, D., Fauler, B., Mielke, T., Mages, N., Herrmann, B. G., Sers, C., Blüthgen, N., & Morkel, M. (2019). Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium. Nature communications, 10(1), 2919.
• Schubert, M., Klinger, B., Klünemann, M., Sieber, A., Uhlitz, F., Sauer, S., Garnett, M. J., Blüthgen, N., & Saez-Rodriguez, J. (2018). Perturbation-response genes reveal signaling footprints in cancer gene expression. Nature communications, 9(1), 20.
• Ünal, E. B., Uhlitz, F., & Blüthgen, N. (2017). A compendium of ERK targets. FEBS letters, 591(17), 2607–2615.
• Schmiedel, J. M., Klemm, S. L., Zheng, Y., Sahay, A., Blüthgen, N., Marks, D. S., & van Oudenaarden, A. (2015). Gene expression. MicroRNA control of protein expression noise. Science (New York, N.Y.), 348(6230), 128–132.
• Murakawa, Y., Hinz, M., Mothes, J., Schuetz, A., Uhl, M., Wyler, E., Yasuda, T., Mastrobuoni, G., Friedel, C. C., Dölken, L., Kempa, S., Schmidt-Supprian, M., Blüthgen, N., Backofen, R., Heinemann, U., Wolf, J., Scheidereit, C., & Landthaler, M. (2015). RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway. Nature communications, 6, 7367.
• Bastiaens, P., Birtwistle, M. R., Blüthgen, N., Bruggeman, F. J., Cho, K. H., Cosentino, C., de la Fuente, A., Hoek, J. B., Kiyatkin, A., Klamt, S., Kolch, W., Legewie, S., Mendes, P., Naka, T., Santra, T., Sontag, E., Westerhoff, H. V., & Kholodenko, B. N. (2015). Silence on the relevant literature and errors in implementation. Nature biotechnology, 33(4), 336–339.
• Schulz, E. G., Meisig, J., Nakamura, T., Okamoto, I., Sieber, A., Picard, C., Borensztein, M., Saitou, M., Blüthgen, N., & Heard, E. (2014). The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network. Cell stem cell, 14(2), 203–216.
• HHerzel, H., & Blüthgen, N. (2008). Mathematical models in mammalian cell biology. Genome biology, 9(7), 316.